Research area: Musculoskeletal Diseases

Description

The group resulted from the initiative of general practitioners from the primary care region Barcelona Litoral and Dreta de l’Eixample, in collaboration with the Bone and Joint Pathophysiology Research Unit of the IMIM-Parc de Salut Mar. From 2009 the group collaborates with the Epidemiology Unit of the Orthopaedics, Rheumatology and Musculoskeletal Sciences at the University of Oxford. The group aims to study the risk factors of the most common musculoskeletal disorders (osteoporosis and osteoarthritis) from a primary care perspective and the effectiveness of the treatments currently available.

Research Lines

Epidemiology of the most frequent diseases of the musculoskeletal system in primary care: osteoarthritis and osteoporosis, Epidemiology of the adherence to the most common treatments for musculoskeletal disorders, Pharmaco-epidemiology and potential new uses for these treatments, Patient-reported outcomes of hip and knee arthroplasty as a treatment for osteoarthritis, Epidemiology of other disorders of the musculoskeletal system from a primary care perspective.

Members

Projects

The group participates in the following projects:

PI:Prieto Alhambra, Daniel. Secular trends of total knee/hip arthroplasty, related complications, and healthcare resource use in patients with inflammatory arthropathies compared to osteoarthritis: a binational cohort study. Funding: IDIAP Jordi Gol. Duration: 2016 - 2018

PI: Prieto Alhambra, Daniel. Multinational database cohort study to assess RMP specified safety outcomes in association with indacaterol/glycopyrronium bromide in Europe. QVA149A2402. Funding: Synapse Research Management Partners, SL. Duration: 2014 - 2018

PI: Prieto Alhambra, Daniel. Multinational, multi-database cohort study to assess adverse cardiovascular and cerebrovascular outcomes and mortality in association with inhaled NVA237 in Europe. Funding: Synapse Research Management Partners, S.L. Duration: 2013 - 2018

PI: Ramos Blanes, Rafel. Real world Outcomes across the AD spectrum to better care: Multi-modal data Access Platform. Funding: Innovative Medicines Initiative (IMI). Duration: 2016 - 2017

PI: Prieto Alhambra, Daniel. European Program of Post-Authorisation Safety Studies for Protelos®/Osseor® through EU-ADR Alliance. Funding: Synapse Research Management Partners, S.L. Duration: 2015 - 2017

PI: Prieto Alhambra, Daniel. European Program of Post-Authorisation Safety Studies for Protelos®/Osseor® through EU-ADR Alliance. Funding: Synapse Research Management Partners, S.L. Duration: 2015 - 2017

PI: Prieto Alhambra, Daniel. Efectivitat i seguretat dels tractaments anti-osteoporosi a Catalunya: estudi de cohorts de base poblacional. Funding: IDIAP Jordi Gol. Duration: 2015 - 2017

PI: Díez Pérez, Adolf. Epidemiología de las fracturas en la insuficiencia renal crónica y riesgo/beneficio de los bisfosfonatos en pacientes con insuficiencia renal crónica. Funding: Fundació Institut Mar Investigacions Mèdiques. Duration: 2016

PI: Prieto Alhambra, Daniel. A multi-database cohort study to assess the incidence rates of colorectal hyperplasia among hypertensive patients. Funding: Synapse Research Management Partners, S.L. Duration: 2016

PI: Nogues Solan, Xavier. Estudi dels efectes dels inhibidors d'aromatasa sobre la salut òssia i cardiovascular en dones amb càncer de mama. Funding: Fundació Institut Mar Investigacions Mèdiques. Duration: 2016

PI: Prieto Alhambra, Daniel. Non-interventional post-authorization multi-database safety study to assess the risk of myotoxicity and hepatotoxicity in statin-exposed heart failure patients with or without concomitant use of LCZ696. Funding: Synapse Research Management Partners, S.L. Duration: 2016

PI: Prieto Alhambra, Daniel. Non-interventional post-authorization multi-database safety study to further characterize specific safety outcomes in association with use of Entresto® (sacubitril/valsartan) in patients with heart failure. Safety. Funding: Synapse Research Management Partners, S.L. Duration: 2016

PI: Prieto Alhambra, Daniel. A multi-database cohort study to assess the incidence rates of colorectal hyperplasia among hypertensive patients. Funding: Synapse Research Management Partners, S.L. Duration: 2015 - 2016

PI: Prieto Alhambra, Daniel. Persistence with Osteoporosis Medications in Postmenopausal Women in Catalonia (Spain): a Population Based Retrospective Analysis. Funding: Amgen, S.A.. Duration: 2015 - 2016

PI: Prieto Alhambra, Daniel. Asociación entre el uso de fármacos anti-osteoporosis y medicamentos anti-diabéticos y riesgo de fractura sintomática en pacientes con Diabetes Mellitus tipo 2. Funding: FEIOMM. Duration: 2015 - 2016

PI: Morros Pedrós, Rosa. Uso de heparinas y nuevos anticoagulantes en atención primaria en Cataluña. Estudio Piloto. Funding: Bioiberica, S.A.U.. Duration: 2015 - 2016

PI: Prieto Alhambra, Daniel. Multinational, multi-database drug utilization study of indacaterol/glycopyrronium bromide in Europe. QVA149A2401. Funding: Synapse Research Management Partners, S.L. Duration: 2014 - 2016

PI: Prieto Alhambra, Daniel. European Program of Post-Authorisation Safety Studies for Protelos®/Osseor® through EU-ADR Alliance. Funding: Synapse Research Management Partners, S.L. Duration: 2014 - 2016

PI: Prieto Alhambra, Daniel. Multinational, multi-database cohort study to assess the incidence rate of severe asthma exacerbation and asthma related mortality rates. Funding: Synapse Research Management Partners, S.L. Duration: 2014 - 2016

PI: Prieto Alhambra, Daniel. Multinational, multi-database drug utilization study of inhaled NVA237 in Europe. Funding: Synapse Research Management Partners, S.L. Duration: 2013 - 2016

Publications

The group participates in the following publications:

Abrahamsen B, Eiken P, Prieto-Alhambra D, Eastell R. Risk of hip, subtrochanteric, and femoral shaft fractures among mid and long term users of alendronate: nationwide cohort and nested case-control study. BMJ (Clinical research ed.). 2016 Jun; 353:i3365. Epub 2016 Zer 28. pmc:PMC4924596. PMID:27353596.

Abrahamsen B, Prieto-Alhambra D. Patients With Atypical Femur Fractures Have the Same Mortality as the Background Population-Drug-Channeling Bias, Bisphosphonate Effects, and Public Health Implications. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2016 Mar; 31(3):488-90. doi:10.1002/jbmr.2801. PMID:26840991. FI: 5,622.

Fina-Aviles F, Medina-Peralta M, Mendez-Boo L, Hermosilla E, Elorza JM, Garcia-Gil M, Ramos R, Bolibar B, Javaid MK, Edwards CJ, Cooper C, Arden NK, Prieto-Alhambra D. The descriptive epidemiology of rheumatoid arthritis in Catalonia: a retrospective study using routinely collected data. Clin Rheumatol. 2016 Mar;35(3):751-7. doi: 10.1007/s10067-014-2801-1. Epub 2014 Oct 26. PubMed PMID: 25344777. FI: 2,042.

Güerri-Fernández R, Molina D, Villar-García J, Prieto-Alhambra D, Mellibovsky L, Nogués X, González-Mena A, Guelar A, Trenchs-Rodríguez M, Herrera-Fernández S, Horcajada JP, Díez-Pérez A, Knobel H. Brief Report: HIV Infection Is Associated With Worse Bone Material Properties, Independently of Bone Mineral Density. Journal of acquired immune deficiency syndromes (1999). 2016 Jul; 72(3):314-8. doi:10.1097/QAI.0000000000000965. PMID:26910501. FI: 3,806.

Hawley S, Javaid MK, Prieto-Alhambra D, Lippett J, Sheard S, Arden NK, Cooper C, Judge A; REFReSH study group. Clinical effectiveness of orthogeriatric and fracture liaison service models of care for hip fracture patients: population-based longitudinal study. Age and ageing. 2016 Mar; 45(2):236-42. doi:10.1093/ageing/afv204. Epub 2016 Jan 21. pmc:PMC4776625. PMID:26802076. FI: 4,201.

Hawley S, Javaid MK, Rubin KH, Judge A, Arden NK, Vestergaard P, Eastell R, Diez-Perez A, Cooper C, Abrahamsen B, Prieto-Alhambra D. Incidence and Predictors of Multiple Fractures Despite High Adherence to Oral Bisphosphonates: A Binational Population-Based Cohort Study. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2015 Jul; doi:10.1002/jbmr.2595. PMID:26174968. FI: 5,622.

Hawley S, Leal J, Delmestri A, Prieto-Alhambra D, Arden NK, Cooper C, Javaid MK, Judge A; REFReSH Study Group. Anti-Osteoporosis Medication Prescriptions and Incidence of Subsequent Fracture Among Primary Hip Fracture Patients in England and Wales: An Interrupted Time-Series Analysis. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2016 Nov; 31(11):2008-2015. doi:10.1002/jbmr.2882. Epub 2016 Jul 04. pmc:PMC5122450. PMID:27377877. FI: 5,622.

Leal J, Gray AM, Prieto-Alhambra D, Arden NK, Cooper C, Javaid MK, Judge A; REFReSH study group. Impact of hip fracture on hospital care costs: a population-based study. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 2016 Feb; 27(2):549-58. doi:10.1007/s00198-015-3277-9. Epub 2015 Aug 19. pmc:PMC4740562. PMID:26286626. FI: 3,445.

Leyland KM, Arden NK, Prieto-Alhambra D. Reply. Arthritis & rheumatology (Hoboken, N.J.). 2016 Jun; 68(6):1567-8. doi:10.1002/art.39578. PMID:26748570. FI: 6,009. Leyland KM, Judge A, Javaid MK, Diez-Perez A, Carr A, Cooper C, Arden NK, Prieto-Alhambra D. Obesity and the Relative Risk of Knee Replacement Surgery in Patients With Knee Osteoarthritis: A Prospective Cohort Study. Arthritis & rheumatology (Hoboken, N.J.). 2016 Apr; 68(4):817-25. doi:10.1002/art.39486. PMID:26556722. FI: 6,009.

Malak TT, Broomfield JA, Palmer AJ, Hopewell S, Carr A, Brown C, Prieto-Alhambra D, Glyn-Jones S. Surrogate markers of long-term outcome in primary total hip arthroplasty: A systematic review. Bone & joint research. 2016 Jun; 5(6):206-14. doi:10.1302/2046-3758.56.2000568. pmc:PMC4921042. PMID:27267795. FI: .

Reyes C, Hitz M, Prieto-Alhambra D, Abrahamsen B. Risks and Benefits of Bisphosphonate Therapies. Journal of cellular biochemistry. 2016 Jan; 117(1):20-8. doi:10.1002/jcb.25266. PMID:26096687. FI: 3,446.

Reyes C, Leyland KM, Peat G, Cooper C, Arden NK, Prieto-Alhambra D. Association Between Overweight and Obesity and Risk of Clinically Diagnosed Knee, Hip, and Hand Osteoarthritis: A Population-Based Cohort Study. Arthritis & rheumatology (Hoboken, N.J.). 2016 Aug; 68(8):1869-75. doi:10.1002/art.39707. pmc:PMC4966641. PMID:27059260. FI: 6,009.

Reyes C, Pottegård A, Schwarz P, Javaid MK, Van Staa TP, Cooper C, Diez-Perez A, Abrahamsen B, Prieto-Alhambra D. Real-Life and RCT Participants: Alendronate Users Versus FITs' Trial Eligibility Criterion. Calcified tissue international. 2016 Sep; 99(3):243-9. doi:10.1007/s00223-016-0141-7. Epub 2016 Apr 20. PMID:27099132. FI: 3,052.

Rodríguez-Sanz M, Prieto-Alhambra D, Servitja S, Garcia-Giralt N, Garrigos L, Rodriguez-Morera J, Albanell J, Martínez-García M, González I, Diez-Perez A, Tusquets I, Nogués X. AI-related BMD variation in actual practice conditions: A prospective cohort study. Endocrine-related cancer. 2016 Apr; 23(4):303-12. doi:10.1530/ERC-16-0025. Epub 2016 Feb 24. PMID:26911377. FI: 4,472.

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