Àrea de Recerca: Aparell Locomotor

Descripció

El grup es va originar a partir de la iniciativa dels metges generals de la regió d'atenció primària de Barcelona Litoral i Dreta de l'Eixample, en col•laboració amb la Unitat de Recerca en Fisiologia i Fisiopatologia Mixta de l'IMIM-Parc de Salut Mar. Des del 2009 el grup col•labora amb l'Epidemiologia Unitat de Ortopèdia, Reumatologia i Ciències Musculoesquelètiques a la Universitat d'Oxford. El grup pretén estudiar els factors de risc dels trastorns musculoesquelètics més freqüents (osteoporosi i osteoartritis) des d'una perspectiva d'atenció primària i l'eficàcia dels tractaments disponibles actualment.

Línies de treball

Epidemiologia de les malalties més freqüents del sistema musculoesquelètic en l'atenció primària: osteoartritis i osteoporosi; Epidemiologia de l'adhesió als tractaments més freqüents per a trastorns musculoesquelètics; Farmacoeducologia i nous usos potencials per a aquests tractaments; Resultats reportats per la malaltia del maluc i artroplàstia del genoll com a tractament per a l'osteoartritis; Epidemiologia d'altres trastorns del sistema musculoesquelètic des d'una perspectiva d'atenció primària.

Membres

Projectes

El grup participa en els projectes següents:

IP: IP: Prieto Alhambra, Daniel. Secular trends of total knee/hip arthroplasty, related complications, and healthcare resource use in patients with inflammatory arthropathies compared to osteoarthritis: a binational cohort study. Entitat finançadora: IDIAP Jordi Gol. Durada: 2016 - 2018

IP: Prieto Alhambra, Daniel. Multinational database cohort study to assess RMP specified safety outcomes in association with indacaterol/glycopyrronium bromide in Europe. QVA149A2402. Entitat finançadora: Synapse Research Management Partners, SL. Durada: 2014 - 2018

IP: Prieto Alhambra, Daniel. Multinational, multi-database cohort study to assess adverse cardiovascular and cerebrovascular outcomes and mortality in association with inhaled NVA237 in Europe. Entitat finançadora: Synapse Research Management Partners, S.L. Durada: 2013 - 2018

IP: Ramos Blanes, Rafel. Real world Outcomes across the AD spectrum to better care: Multi-modal data Access Platform. Entitat finançadora: Innovative Medicines Initiative (IMI). Durada: 2016 - 2017

IP: Prieto Alhambra, Daniel. European Program of Post-Authorisation Safety Studies for Protelos®/Osseor® through EU-ADR Alliance. Entitat finançadora: Synapse Research Management Partners, SL. Durada: 2015 - 2017

IP: Prieto Alhambra, Daniel. Efectivitat i seguretat dels tractaments anti-osteoporosi a Catalunya: estudi de cohorts de base poblacional. Entitat finançadora: IDIAP Jordi Gol. Durada: 2015 - 2017

IP: Díez Pérez, Adolf. Epidemiología de las fracturas en la insuficiencia renal crónica y riesgo/beneficio de los bisfosfonatos en pacientes con insuficiencia renal crónica. Entitat finançadora: Fundació Institut Mar Investigacions Mèdiques. Durada: 2016

IP: Prieto Alhambra, Daniel. A multi-database cohort study to assess the incidence rates of colorectal hyperplasia among hypertensive patients. Entitat finançadora: Synapse Research Management Partners, S.L. Durada: 2016

IP: Nogues Solan, Xavier. Estudi dels efectes dels inhibidors d'aromatasa sobre la salut òssia i cardiovascular en dones amb càncer de mama. Entitat finançadora: Fundació Institut Mar Investigacions Mèdiques. Durada: 2016

IP: Prieto Alhambra, Daniel. Non-interventional post-authorization multi-database safety study to assess the risk of myotoxicity and hepatotoxicity in statin-exposed heart failure patients with or without concomitant use of LCZ696. Entitat finançadora: Synapse Research Management Partners, S.L. Durada: 2016

IP: Prieto Alhambra, Daniel. Non-interventional post-authorization multi-database safety study to further characterize specific safety outcomes in association with use of Entresto® (sacubitril/valsartan) in patients with heart failure. Safety. Entitat finançadora: Synapse Research Management Partners, S.L. Durada: 2016

IP: Prieto Alhambra, Daniel. A multi-database cohort study to assess the incidence rates of colorectal hyperplasia among hypertensive patients. Entitat finançadora: Synapse Research Management Partners, S.L. Durada: 2015 - 2016

IP: Prieto Alhambra, Daniel. Persistence with Osteoporosis Medications in Postmenopausal Women in Catalonia (Spain): a Population Based Retrospective Analysis. Entitat finançadora: Amgen, S.A. Durada: 2015 - 2016

IP: Prieto Alhambra, Daniel. Asociación entre el uso de fármacos anti-osteoporosis y medicamentos anti-diabéticos y riesgo de fractura sintomática en pacientes con Diabetes Mellitus tipo 2. Entitat finançadora: FEIOMM. Durada: 2015 - 2016

IP: Morros Pedrós, Rosa. Uso de heparinas y nuevos anticoagulantes en atención primaria en Cataluña. Estudio Piloto. Entitat finançadora: Bioiberica, S.A.U.. Durada: 2015 - 2016

IP: Prieto Alhambra, Daniel. Multinational, multi-database drug utilization study of indacaterol/glycopyrronium bromide in Europe. QVA149A2401. Entitat finançadora: Synapse Research Management Partners, S.L. Durada: 2014 - 2016

IP: Prieto Alhambra, Daniel. European Program of Post-Authorisation Safety Studies for Protelos®/Osseor® through EU-ADR Alliance. Entitat finançadora: Synapse Research Management Partners, S.L. Durada: 2014 - 2016

IP: Prieto Alhambra, Daniel. Multinational, multi-database cohort study to assess the incidence rate of severe asthma exacerbation and asthma related mortality rates. Entitat finançadora: Synapse Research Management Partners, S.L. Durada: 2014 - 2016

IP: Prieto Alhambra, Daniel. Multinational, multi-database drug utilization study of inhaled NVA237 in Europe. Entitat finançadora: Synapse Research Management Partners, S.L. Durada: 2013 - 2016

Publicacions

El grup participa en els articles següents:

Abrahamsen B, Eiken P, Prieto-Alhambra D, Eastell R. Risk of hip, subtrochanteric, and femoral shaft fractures among mid and long term users of alendronate: nationwide cohort and nested case-control study. BMJ (Clinical research ed.). 2016 Jun; 353:i3365. Epub 2016 Zer 28. pmc:PMC4924596. PMID:27353596.

Abrahamsen B, Prieto-Alhambra D. Patients With Atypical Femur Fractures Have the Same Mortality as the Background Population-Drug-Channeling Bias, Bisphosphonate Effects, and Public Health Implications. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2016 Mar; 31(3):488-90. doi:10.1002/jbmr.2801. PMID:26840991. FI: 5,622.

Fina-Aviles F, Medina-Peralta M, Mendez-Boo L, Hermosilla E, Elorza JM, Garcia-Gil M, Ramos R, Bolibar B, Javaid MK, Edwards CJ, Cooper C, Arden NK, Prieto-Alhambra D. The descriptive epidemiology of rheumatoid arthritis in Catalonia: a retrospective study using routinely collected data. Clin Rheumatol. 2016 Mar;35(3):751-7. doi: 10.1007/s10067-014-2801-1. Epub 2014 Oct 26. PubMed PMID: 25344777. FI: 2,042.

Güerri-Fernández R, Molina D, Villar-García J, Prieto-Alhambra D, Mellibovsky L, Nogués X, González-Mena A, Guelar A, Trenchs-Rodríguez M, Herrera-Fernández S, Horcajada JP, Díez-Pérez A, Knobel H. Brief Report: HIV Infection Is Associated With Worse Bone Material Properties, Independently of Bone Mineral Density. Journal of acquired immune deficiency syndromes (1999). 2016 Jul; 72(3):314-8. doi:10.1097/QAI.0000000000000965. PMID:26910501. FI: 3,806.

Hawley S, Javaid MK, Prieto-Alhambra D, Lippett J, Sheard S, Arden NK, Cooper C, Judge A; REFReSH study group. Clinical effectiveness of orthogeriatric and fracture liaison service models of care for hip fracture patients: population-based longitudinal study. Age and ageing. 2016 Mar; 45(2):236-42. doi:10.1093/ageing/afv204. Epub 2016 Jan 21. pmc:PMC4776625. PMID:26802076. FI: 4,201.

Hawley S, Javaid MK, Rubin KH, Judge A, Arden NK, Vestergaard P, Eastell R, Diez-Perez A, Cooper C, Abrahamsen B, Prieto-Alhambra D. Incidence and Predictors of Multiple Fractures Despite High Adherence to Oral Bisphosphonates: A Binational Population-Based Cohort Study. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2015 Jul; doi:10.1002/jbmr.2595. PMID:26174968. FI: 5,622.

Hawley S, Leal J, Delmestri A, Prieto-Alhambra D, Arden NK, Cooper C, Javaid MK, Judge A; REFReSH Study Group. Anti-Osteoporosis Medication Prescriptions and Incidence of Subsequent Fracture Among Primary Hip Fracture Patients in England and Wales: An Interrupted Time-Series Analysis. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2016 Nov; 31(11):2008-2015. doi:10.1002/jbmr.2882. Epub 2016 Jul 04. pmc:PMC5122450. PMID:27377877. FI: 5,622.

Leal J, Gray AM, Prieto-Alhambra D, Arden NK, Cooper C, Javaid MK, Judge A; REFReSH study group. Impact of hip fracture on hospital care costs: a population-based study. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 2016 Feb; 27(2):549-58. doi:10.1007/s00198-015-3277-9. Epub 2015 Aug 19. pmc:PMC4740562. PMID:26286626. FI: 3,445.

Leyland KM, Arden NK, Prieto-Alhambra D. Reply. Arthritis & rheumatology (Hoboken, N.J.). 2016 Jun; 68(6):1567-8. doi:10.1002/art.39578. PMID:26748570. FI: 6,009. Leyland KM, Judge A, Javaid MK, Diez-Perez A, Carr A, Cooper C, Arden NK, Prieto-Alhambra D. Obesity and the Relative Risk of Knee Replacement Surgery in Patients With Knee Osteoarthritis: A Prospective Cohort Study. Arthritis & rheumatology (Hoboken, N.J.). 2016 Apr; 68(4):817-25. doi:10.1002/art.39486. PMID:26556722. FI: 6,009.

Malak TT, Broomfield JA, Palmer AJ, Hopewell S, Carr A, Brown C, Prieto-Alhambra D, Glyn-Jones S. Surrogate markers of long-term outcome in primary total hip arthroplasty: A systematic review. Bone & joint research. 2016 Jun; 5(6):206-14. doi:10.1302/2046-3758.56.2000568. pmc:PMC4921042. PMID:27267795.

Reyes C, Hitz M, Prieto-Alhambra D, Abrahamsen B. Risks and Benefits of Bisphosphonate Therapies. Journal of cellular biochemistry. 2016 Jan; 117(1):20-8. doi:10.1002/jcb.25266. PMID:26096687. FI: 3,446.

Reyes C, Leyland KM, Peat G, Cooper C, Arden NK, Prieto-Alhambra D. Association Between Overweight and Obesity and Risk of Clinically Diagnosed Knee, Hip, and Hand Osteoarthritis: A Population-Based Cohort Study. Arthritis & rheumatology (Hoboken, N.J.). 2016 Aug; 68(8):1869-75. doi:10.1002/art.39707. pmc:PMC4966641. PMID:27059260. FI: 6,009.

Reyes C, Pottegård A, Schwarz P, Javaid MK, Van Staa TP, Cooper C, Diez-Perez A, Abrahamsen B, Prieto-Alhambra D. Real-Life and RCT Participants: Alendronate Users Versus FITs' Trial Eligibility Criterion. Calcified tissue international. 2016 Sep; 99(3):243-9. doi:10.1007/s00223-016-0141-7. Epub 2016 Apr 20. PMID:27099132. FI: 3,052.

Rodríguez-Sanz M, Prieto-Alhambra D, Servitja S, Garcia-Giralt N, Garrigos L, Rodriguez-Morera J, Albanell J, Martínez-García M, González I, Diez-Perez A, Tusquets I, Nogués X. AI-related BMD variation in actual practice conditions: A prospective cohort study. Endocrine-related cancer. 2016 Apr; 23(4):303-12. doi:10.1530/ERC-16-0025. Epub 2016 Feb 24. PMID:26911377. FI: 4,472.

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