Research area: Infectious disease

Description

The main objective of the group is to define the antimicrobial stewardship in primary care in order to rationalise antibiotic use and to target the subgroups of patients that really need to receive antibiotic treatment. Other objectives are to identify the most prevalent causes of infection in the community, better diagnose the different infectious diseases with point-of-care tests, distinguish between bacterial and viral origin and know the level of resistance of common organisms to antimicrobials. This group includes GPs that investigate various aspects of infectious diseases in primary care, together with other professionals such as specialists in respiratory diseases, nurses and statisticians. The group aims to collaborate with microbiology specialists in the near future. GRIP collaborates with the following entities: hospitals (Hospital Vall d'Hebron of Barcelona and Hospital Joan XXIII of Tarragona), universities (Universitat de Barcelona, Universitat Autònoma de Barcelona, Universitat Rovira i Virgili, Cardiff University and University of Copenhagen) and scientific societies (CAMFIC, SemFYC and WONCA).

Research Lines

Rational use of antibiotics in respiratory tract infections; Understand the long-term effectiveness of a multifaceted strategy in the use of antibiotics in respiratory infections, Lower respiratory tract infections; Learn more about the subgroups patients. They can benefit from antibiotic treatment and know the effectiveness of prophylaxis in COPD, otitis media and external. To know the effectiveness of topical antiseptic treatment compared with oral antibiotic therapy in the resolution of acute otorrhea, Acute pharyngitis; To know the etiology of pharyngitis in adults based on microbiological analysis, effectiveness of antibiotic treatment, to know what diagnostic strategy helps make a more reasoned use of antibiotics, Urinary tract infections: Role of rapid diagnostic methods in the reasoned use of antibiotics in these infections.

Members

Projects

The group participates in the following projects:

PI: Llor Vilà, Carles. ¿Antivirales para el tratamiento de enfermedades con síntomas gripales? Ensayo clínico aleatorio de la efectividad clínica y económica en Atención Primaria (ALIC4E). Funding: University of Oxford. Duration: 2016 - 2018

PI: Llor Vilà, Carles. KRISTINA: A Knowledge-Based Information Agent with Social Competence and Human Interaction Capabilities. Funding: SEMFYC. Duration: 2015 - 2017

PI: Llor Vilà, Carles. General Practitioner (GP) use of a C-Reactive Protein (CRP) Point of Care Test to help target antibiotic prescribing to patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD) who are most likely to benefit. Funding: Universitat de Cardiff. Duration: 2014 - 2016

PI: Llor Vilà, Carles. Eficacia de dosis altas de penicilina v oral frente a amoxicilina a dosis altas en el tratamiento de la neumonía no grave atendida en la comunidad en adultos. Funding: Instituto de Salud Carlos III. Duration: 2012 - 2016

Publications

Group Publications:

Alonso-Coello P, Llor C, de la Poza Abad M. Mixed Diagnoses and Mixed Messages-Reply. JAMA internal medicine. 2016 May; 176(5):719. doi:10.1001/jamainternmed.2016.1287. PMID:27136345. FI: 14,000.

Cots JM, Alós JI, Bárcena M, Boleda X, Cañada JL, Gómez N, Mendoza A, Vilaseca I, Llor C. Recommendations for management of acute pharyngitis in adults. Enfermedades infecciosas y microbiologia clinica. 2016 Nov; 34(9):585-594. doi:10.1016/j.eimc.2015.02.010. Epub 2015 Apr 11. Spanish. PMID:25869058. FI: 1,530.

de la Poza Abad M, Mas Dalmau G, Moreno Bakedano M, González González AI, Canellas Criado Y, Hernández Anadón S, Rotaeche del Campo R, Torán Monserrat P, Negrete Palma A, Muñoz Ortiz L, Borrell Thió E, Llor C, Little P, Alonso-Coello P; Delayed Antibiotic Prescription (DAP) Group. Prescription Strategies in Acute Uncomplicated Respiratory Infections: A Randomized Clinical Trial. JAMA internal medicine. 2016 Jan; 176(1):21-9. doi:10.1001/jamainternmed.2015.7088. PMID:26719947. FI: 14,000.

Guinovart MC, Figueras A, Llor C. Selling antimicrobials without prescription - Far beyond an administrative problem. Enfermedades infecciosas y microbiologia clinica. 2016 Nov; doi:10.1016/j.eimc.2016.10.006. Epub 2016 Nov 17. PMID:27866752. FI: 1,530.

Llor C, Bjerrum L. Antibiotic prescribing for acute bronchitis. Expert review of anti-infective therapy. 2016 Jul; 14(7):633-42. doi:10.1080/14787210.2016.1193435. Epub 2016 Zer 08. PMID:27219826. FI: 3,542.

Llor C, Moragas A, Cots JM, López-Valcárcel BG; Happy Audit Study Group. Estimated saving of antibiotics in pharyngitis and lower respiratory tract infections if general practitioners used rapid tests and followed guidelines. Atencion primaria. 2016 Nov; doi:10.1016/j.aprim.2016.07.002. Epub 2016 Nov 21. PMID:27884552. FI: 1,098.

Tonkin-Crine S, Anthierens S, Hood K, Yardley L, Cals JW, Francis NA, Coenen S, van der Velden AW, Godycki-Cwirko M, Llor C, Butler CC, Verheij TJ, Goossens H, Little P; GRACE INTRO/CHAMP consortium. Discrepancies between qualitative and quantitative evaluation of randomised controlled trial results: achieving clarity through mixed methods triangulation. Implementation science: IS. 2016; 11(1):66. doi:10.1186/s13012-016-0436-0. Epub 2016 May 12. pmc:PMC4866290. PMID:27175799. FI: 4,122.

The group participates in the following publications:

Monteagudo M, Rodríguez-Blanco T, Barrecheguren M, Simonet P, Miravitlles M. Prevalence and incidence of bronchiectasis in Catalonia, Spain: A population-based study Respir Med. 2016;121:26-31. PMID:27888988. FI: 3,036.

Barrecheguren M, Monteagudo M, Ferrer J, Borrell E, Llor C, Esquinas C, Miravitlles M. Treatment patterns in COPD patients newly diagnosed in primary care. A population-based study. Respiratory medicine. 2016 Feb; 111:47-53. doi:10.1016/j.rmed.2015.12.004. Epub 2015 Dec 23. PMID:26758585. FI: 3,036.

Barrecheguren M, Monteagudo M, Simonet P, Llor C, Rodriguez E, Ferrer J, Esquinas C, Miravitlles M. Diagnosis of alpha-1 antitrypsin deficiency: a population-based study. Int J Chron Obstruct Pulmon Dis. 2016 May 10;11:999-1004. doi: 10.2147/COPD.S108505. PubMed PMID: 27274221; PubMed Central PMCID:PMC4869627.

Indicators