Research area: Infectious diseases

Description

The EPIVAC group was formed within the primary health services of Tarragona-Valls and comprises a multidisciplinary group of researchers and primary health care professionals. It is a consolidated group accredited by IDIAP Jordi Gol and by AGAUR (agency for the management of university and research grants of the Catalan Generalitat). Basically the group carries out population-based clinical an epidemiological research into infectious respiratory diseases which are preventable by vaccination.

Research Lines

Epidemiology of Community-Acquired Pneumonia (CAP) in the general population, Epidemiology of pneumococcal diseases in the general population, but especially among infants and old people, Evaluation of the effectiveness of the 23-valent pneumococcal polysaccharide vaccine in people over 50 and the heptavalent conjugate vaccine in infants, Evaluation of the effectiveness of the anti-flu vaccine in the general population and in specific high-risk subgroups.

Members

Projects

The group participates in the following projects:

PI: Vila Corcoles, Angel. Efectividad clínica de la vacuna antineumocócica conjugada 13-valente versus vacuna polisacárida 23-valente en los adultos mayores de 50 años: estudio de cohortes de base poblacional. Funding: Instituto de Salud Carlos III. Duration: 2016 - 2018

PI: Bejarano Romero, Ferran. Evaluación de una intervención multifactorial para la reducción del consumo de benzodiacepinas en atención primaria. Ensayo clínico aleatorizado por clusters. Funding: Instituto de Salud Carlos III. Duration: 2016 - 2018

PI: Llor Vilà, Carles. ¿Antivirales para el tratamiento de enfermedades con síntomas gripales? Ensayo clínico aleatorio de la efectividad clínica y económica en Atención Primaria (ALIC4E). Funding: University of Oxford. Duration: 2016 - 2018

PI: Llor Vilà, Carles. KRISTINA: A Knowledge-Based Information Agent with Social Competence and Human Interaction Capabilities. Funding: SEMFYC. Duration: 2015 - 2017

PI: Satué Gracia, Eva María. Eficacia de una aplicación para dispositivos móviles para mejorar la adherencia a dieta y ejercicio en adultos con sobrepeso y obesidad. Ensayo clínico aleatorizado. Funding: IDIAP Jordi Gol. Duration: 2014 - 2016

PI: Llor Vilà, Carles. General Practitioner (GP) use of a C-Reactive Protein (CRP) Point of Care Test to help target antibiotic prescribing to patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD) who are most likely to benefit. Funding: Universitat de Cardiff. Duration: 2014 - 2016

PI: Llor Vilà, Carles. Eficacia de dosis altas de penicilina v oral frente a amoxicilina a dosis altas en el tratamiento de la neumonía no grave atendida en la comunidad en adultos. Funding: Instituto de Salud Carlos III. Duration: 2012 - 2016

Publications

The group participates in the following publications:

Alonso-Coello P, Llor C, de la Poza Abad M. Mixed Diagnoses and Mixed Messages-Reply. JAMA internal medicine. 2016 May; 176(5):719. doi:10.1001/jamainternmed.2016.1287. PMID:27136345. FI: 14,000.

Azeli Y, Barbería E, Jiménez-Herrera M, Bonet G, Valero-Mora E, Lopez-Gomariz A, Lucas-Guarque I, Guillen-Lopez A, Alonso-Villaverde C, Landín I, Torralba P, Jammoul A, Bladé-Creixenti J, Axelsson C, Bardají A. The ReCaPTa study - a prospective out of hospital cardiac arrest registry including multiple sources of surveillance for the study of sudden cardiac death in the Mediterranean area. Scandinavian journal of trauma, resuscitation and emergency medicine. 2016 Oct; 24(1):127. doi:10.1186/s13049-016-0309-1. Epub 2016 Oct 19. pmc:PMC5070156. PMID:27756343.

Barrecheguren M, Monteagudo M, Ferrer J, Borrell E, Llor C, Esquinas C, Miravitlles M. Treatment patterns in COPD patients newly diagnosed in primary care. A population-based study. Respiratory medicine. 2016 Feb; 111:47-53. doi:10.1016/j.rmed.2015.12.004. Epub 2015 Dec 23. PMID:26758585. FI: 3,036.

Barrecheguren M, Monteagudo M, Simonet P, Llor C, Rodriguez E, Ferrer J, Esquinas C, Miravitlles M. Diagnosis of alpha-1 antitrypsin deficiency: a population-based study. Int J Chron Obstruct Pulmon Dis. 2016 May 10;11:999-1004. doi: 10.2147/COPD.S108505. PubMed PMID: 27274221; PubMed Central PMCID:PMC4869627.

Cots JM, Alós JI, Bárcena M, Boleda X, Cañada JL, Gómez N, Mendoza A, Vilaseca I, Llor C. Recommendations for management of acute pharyngitis in adults. Enfermedades infecciosas y microbiologia clinica. 2016 Nov; 34(9):585-594. doi:10.1016/j.eimc.2015.02.010. Epub 2015 Apr 11. Spanish. PMID:25869058. FI: 1,530.

de la Poza Abad M, Mas Dalmau G, Moreno Bakedano M, González González AI, Canellas Criado Y, Hernández Anadón S, Rotaeche del Campo R, Torán Monserrat P, Negrete Palma A, Muñoz Ortiz L, Borrell Thió E, Llor C, Little P, Alonso-Coello P; Delayed Antibiotic Prescription (DAP) Group. Prescription Strategies in Acute Uncomplicated Respiratory Infections: A Randomized Clinical Trial. JAMA internal medicine. 2016 Jan; 176(1):21-9. doi:10.1001/jamainternmed.2015.7088. PMID:26719947. FI: 14,000.

Guinovart MC, Figueras A, Llor C. Selling antimicrobials without prescription - Far beyond an administrative problem. Enfermedades infecciosas y microbiologia clinica. 2016 Nov; doi:10.1016/j.eimc.2016.10.006. Epub 2016 Nov 17. PMID:27866752. FI: 1,530.

Llor C, Bjerrum L. Antibiotic prescribing for acute bronchitis. Expert review of anti-infective therapy. 2016 Jul; 14(7):633-42. doi:10.1080/14787210.2016.1193435. Epub 2016 Zer 08. PMID:27219826. FI: 3,542.

Llor C, Moragas A, Cots JM, López-Valcárcel BG; Happy Audit Study Group. Estimated saving of antibiotics in pharyngitis and lower respiratory tract infections if general practitioners used rapid tests and followed guidelines. Atencion primaria. 2016 Nov; doi:10.1016/j.aprim.2016.07.002. Epub 2016 Nov 21. PMID:27884552. FI: 1,098.

Lonial S, Weiss BM, Usmani SZ, Singhal S, Chari A, Bahlis NJ, Belch A, Krishnan A, Vescio RA, Mateos MV, Mazumder A, Orlowski RZ, Sutherland HJ, Bladé J, Scott EC, Oriol A, Berdeja J, Gharibo M, Stevens DA, LeBlanc R, Sebag M, Callander N, Jakubowiak A, White D, de la Rubia J, Richardson PG, Lisby S, Feng H, Uhlar CM, Khan I, Ahmadi T, Voorhees PM. Daratumumab monotherapy in patients with treatment-refractory multiple myeloma (SIRIUS): an open-label, randomised, phase 2 trial. Lancet (London, England). 2016 Apr; 387(10027):1551-60. doi:10.1016/S0140-6736(15)01120-4. Epub 2016 Jan 07. PMID:26778538. FI: 44,002.

Satue E, Vila-Corcoles A, Ochoa-Gondar O, de Diego C, Forcadell MJ, Rodriguez-Blanco T, Barnes L, Jariod M. Incidence and risk conditions of ischemic stroke in older adults. Acta neurologica Scandinavica. 2016 Oct; 134(4):250-7. doi:10.1111/ane.12535. Epub 2015 Nov 23. PMID:26592375. FI: 2,559.

Tonkin-Crine S, Anthierens S, Hood K, Yardley L, Cals JW, Francis NA, Coenen S, van der Velden AW, Godycki-Cwirko M, Llor C, Butler CC, Verheij TJ, Goossens H, Little P; GRACE INTRO/CHAMP consortium. Discrepancies between qualitative and quantitative evaluation of randomised controlled trial results: achieving clarity through mixed methods triangulation. Implementation science: IS. 2016; 11(1):66. doi:10.1186/s13012-016-0436-0. Epub 2016 May 12. pmc:PMC4866290. PMID:27175799. FI: 4,122.

Vicens C, Sempere E, Bejarano F, Socias I, Mateu C, Fiol F, Palop V, Mengual M, Folch S, Lera G, Basora J, Leiva A. Efficacy of two interventions on the discontinuation of benzodiazepines in long-term users: 36-month follow-up of a cluster randomised trial in primary care. The British journal of general practice : the journal of the Royal College of General Practitioners. 2016 Feb; 66(643):e85-91. doi:10.3399/bjgp16X683485. pmc:PMC4723219. PMID:26823269. FI: 2,741.

Vila A, Hospital I, Ochoa O, de Diego C, Satué EM, Aragón M. Prevalence of High-Risk Underlying Conditions for Pneumococcal Disease Among People Over 50 Years in Catalonia, Spain. Prim Health Care. 2016;6:234. doi: 10.4172/2167-1079.1000234.

Vila-Corcoles A, Ochoa-Gondar O, Hospital I, de Diego C, Satué E, Bladé J, Ansa X, Guzmán JA, Salsench E, Ramos F. Pneumococcal vaccination coverages among low-, intermediate-, and high-risk adults in Catalonia. Human vaccines & immunotherapeutics. 2016 Jul; doi:10.1080/21645515.2016.1210744. Epub 2016 Zer 25. PMID:27454779. FI: 2,146.

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