Research area: Diabetes

Description

The group is made up of family doctors from the Catalan Health Institute (ICS) with wide experience in the world of diabetes. All of them collaborate with other research groups or scientific societies such as the Spanish Diabetes Society, CAMFiC-SEMFyC, SEMERGEN, or CIBER-DM, and notably in coordination with the group GEDAPS Catalunya and the RedGEDAPS Espanya. It has also collaborated in drawing up the National Health System’s diabetes strategy and the Diabetes mellitus type 2 Clinical Practice Guide for the Instituto de Salud Carlos III and the Ministry of Health. The Catalan Advisory Council on Diabetes systematically uses the group’s data to prepare its recommendations.

The group’s main objective is the study of Diabetes mellitus type 2 in primary health care through epidemiological studies based on the exhaustive analysis of the data obtained from e-CAP (electronic clinical records), which will provide demographic and epidemiological information as well as better knowledge of metabolic control, the coexistence of other risk factors, the presence of complications, treatment compliance and therapeutic inertia.

Research Lines

Metabolic control of type 2 diabetes;Chronic complications of type 2 diabetes; Diseases associated with type 2 diabetes;Mortality in diabetes patients.

Members

Projects

Group projects:

PI: Mata Cases, José Manuel. COSMODIA (COSt analysis using the Core Diabetes MOdel in Type 2 DIAbetes) Análisis de los datos del Estudio eCostesDM (costes de la atención al paciente con DM2 en Catalunya) mediante la aplicación de un modelo matemático (Core Diabetes Model) en colaboración con el York Health Economics Consortium de la Universitat de York. Duration: 2016 - 2018

PI: Mauricio Puente, Dídac. Estudio transversal para analizar la epidemiología de la DM1 con la base de datos SIDIAP. eControl epiDM1. Funding: Lilly, S.A. Duration: 2016 - 2018

PI: Mata Cases, José Manuel. Prevalence of comorbidities among type 2 diabetes mellitus (T2DM) patients in Spain. Funding: Merck Sharp & Dohme de España, S.A. Duration: 2016 - 2018

PI: Mata Cases, José Manuel. Inercia terapéutica en los pacientes con Diabetes tipo 2 tratados con dos o más antidiabéticos no insulínicos seguidos durante 7 años en un registro poblacional. Funding: Sanofi Aventis, S.A. Duration: 2015 - 2017

PI: Molló Iniesta, M.Angels. Estudio INTEGRA: estrategia de INTervención intEgral en pacientes con mal control Glucémico de la diabetes mellitus tipo 2 en el Ámbito de Atención Primaria. Funding: Sanofi Aventis, S.A. Duration: 2014 - 2017

PI: Franch Nadal, Josep. Prevalença del trastorn mental sever en els pacient diabètics de la població de Barcelona ciutat. Funding: ICS - Institut Català de la Salut. Duration: 2016 - 2016

The group participates in the following projects:

PI: Pedrós Cholvi, Consuelo. Riesgo de acidosis láctica asociado al uso de metformina en pacientes diabéticos tipo 2 con enfermedad renal crónica moderada-severa: estudio de casos y controles. Funding: Instituto de Salud Carlos III. Duration: 2016 - 2018

PI: Alzamora Sas, Mª Teresa. Morbimortalidad cardiovascular y no cardiovascular a los 10 años de seguimiento de la cohorte poblacional ARTPER. Funding: Instituto de Salud Carlos III. Duration: 2016 - 2018

PI: Cerezo Goyeneche, Carlos. Ensayo híbrido de evaluación de una intervención compleja multiriesgo para promover conductas saludables en personas de 45-75 años atendidas en Atención Primaria: estudio EIRA3. Subproyecto Girona. Funding: Instituto de Salud Carlos III. Duration: 2016 - 2018

PI: Clua Espuny, Josep Lluis. Atrial Fibrillation Research in CATalonia (AFRICAT): sequential clinicelectro-biological screening among high risk individuals. Funding: Fundacio La Marato de TV3. Duration: 2016 - 2018

PI: Coll de Tuero, Gabriel. Comportamiento dinámico del síndrome metabólico y elaboración de una ecuación para predecir el riesgo cardiovascular en los pacientes con Diabetes tipo 2 de una cohorte retrospectiva obtenida a partir de una base de datos clínico administrativa. Funding: Instituto de Salud Carlos III. Duration: 2016 - 2018

PI: Costa Pinel, Bernardo. Diabetes Prevention - Translating a feasible and cost-effective lifestyle intervention into primary care to reduce the social burden of type 2 diabetes. Funding: Fundacio La Marato de TV3. Duration: 2016 - 2018

PI: Costa Pinel, Bernardo. Diabetes Prevention - Translating a feasible and cost-effective lifestyle intervention into primary care to reduce the social burden of type 2 diabetes. Funding: Instituto de Salud Carlos III. Duration: 2015 - 2017

PI: Barrio Torrell, Francisco. Rendimiento de la nueva escala nacional de riesgo CATDRISC para cribar y predecir a 10 años la diabetes tipo 2 en la cohorte DE-PLAN-CAT. Funding: Instituto de Salud Carlos III. Duration: 2015 - 2017

PI: Delgado Martínez, María Pilar. Influencia del tipo de tratamiento antihipertensivo prescrito en la práctica clínica habitual sobre la variabilidad de la presión arterial y el riesgo cardiovascular del hipertenso. Funding: Instituto de Salud Carlos III. Duration: 2015 - 2017

PI: Muñoz Pérez, Miguel Angel. Factores pronósticos de mortalidad a corto plazo en enfermos con Insuficiencia cardiaca avanzada: Estudio HADES. Funding: IDIAP Jordi Gol. Duration: 2015 - 2017

PI: Costa Pinel, Bernardo. Early Prevention of Diabetes Complications in people with Hyperglycaemia in Europe. Funding: IDIAP Jordi Gol. Duration: 2013 - 2017

PI: Costa Pinel, Bernardo. Early Prevention of Diabetes Complications in people with Hyperglycaemia in Europe. Funding: European Commission. Duration: 2011 - 2017

PI: Costa Pinel, Bernardo. Traslación a la atención primaria de una intervención factible y coste-efectiva sobre el estilo de vida para reducir el impacto de la diabetes tipo 2. Funding: Sociedad Española Diabetes. Duration: 2016

PI: Benítez Camps, Mència. Evaluación de la relación entre paracetamol efervescente y presión arterial. Ensayo clínico. Funding: Reunions i Ciència, S.L. Duration: 2016

PI: Prieto Alhambra, Daniel. Asociación entre el uso de fármacos anti-osteoporosis y medicamentos anti-diabéticos y riesgo de fractura sintomática en pacientes con Diabetes Mellitus tipo 2. Funding: FEIOMM. Duration: 2015 - 2016

PI: Muñoz Pérez, Miguel Angel. Epidemiology of Heart Failure in Catalonia: a cohort study. Funding: Novartis Pharma AG. Duration: 2015 - 2016

Publications

Group Publications:

Berenguera A, Molló M, Mata-Cases M, Franch J, Bolíbar B, Mauricio D. Understanding the physical, social, and emotional experiences of people with uncontrolled Type 2 diabetes: a qualitative study. Patient Preference Adherence. 2016;10:2323-2332. PMID:27877024. FI: 1,718.

Escalada J, Orozco-Beltran D, Morillas C, Alvarez-Guisasola F, Gomez-Peralta F, Mata-Cases M, Palomares R, Iglesias R, Carratalá-Munuera C. Attitudes towards insulin initiation in type 2 diabetes patients among healthcare providers: A survey research. Diabetes research and clinical practice. 2016 Dec; 122:46-53. doi:10.1016/j.diabres.2016.10.003. Epub 2016 Oct 14. PMID:27810685. FI: 3,045.

Mata-Cases M, Casajuana M, Franch-Nadal J, Casellas A, Castell C, Vinagre I, Mauricio D, Bolíbar B. Direct medical costs attributable to type 2 diabetes mellitus: a population-based study in Catalonia, Spain. The European journal of health economics : HEPAC : health economics in prevention and care. 2016 Nov; 17(8):1001-1010. doi:10.1007/s10198-015-0742-5. Epub 2015 Nov 05. pmc:PMC5047944. PMID:26542160.

Mata-Cases M, Franch-Nadal J, Real J, Mauricio D. Glycaemic control and antidiabetic treatment trends in primary care centres in patients with type 2 diabetes mellitus during 2007-2013 in Catalonia: a population-based study. BMJ open. 2016 Oct; 6(10):e012463. doi:10.1136/bmjopen-2016-012463. Epub 2016 Zer 5. PMID:27707830. FI: 2,562.

Mata-Cases M, Mauricio D, Real J, Bolíbar B, Franch-Nadal J. Is diabetes mellitus correctly registered and classified in primary care? A population-based study in Catalonia, Spain. Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion. 2016 Nov; 63(9):440-448. doi:10.1016/j.endonu.2016.07.004. Epub 2016 Sep 06. PMID:27613079.

Rodríguez-Poncelas A, Mundet-Tudurí X, Miravet-Jiménez S, Casellas A, Barrot-De la Puente JF, Franch-Nadal J, Coll-de Tuero G. Chronic Kidney Disease and Diabetic Retinopathy in Patients with Type 2 Diabetes. PLoS One. 2016 Feb 17;11(2):e0149448. doi: 10.1371/journal.pone.0149448. eCollection 2016. PubMed PMID: 26886129; PubMed Central PMCID: PMC4757564. FI: 3,057.

Rubinat E, Marsal JR, Vidal T, Cebrian C, Falguera M, Vilanova MB, Betriu À, Fernández E, Franch J, Mauricio D. Subclinical Carotid Atherosclerosis in Asymptomatic Subjects With Type 2 Diabetes Mellitus. The Journal of cardiovascular nursing. 2016 Mar-Apr; 31(2):E1-7. doi:10.1097/JCN.0000000000000236. PMID:25829137. FI: 2,172.

Ruiz-Tamayo I, Franch-Nadal J, Mata-Cases M, Mauricio D, Cos X, Rodriguez-Poncelas A, Barrot J, Coll-de-Tuero G, Mundet-Tudurí X. Noninsulin Antidiabetic Drugs for Patients with Type 2 Diabetes Mellitus: Are We Respecting Their Contraindications? J Diabetes Res. 2016;2016:7502489. doi:10.1155/2016/7502489. Epub 2016 Jan 6. PubMed PMID: 26881258; PubMed Central PMCID: PMC4736814. FI: 2,431.

The group participates in the following publications:

Alcubierre N, Martinez-Alonso M, Valls J, Rubinat E, Traveset A, Hernández M, Martínez-González MD, Granado-Casas M, Jurjo C, Vioque J, Navarrete-Muñoz EM, Mauricio D. Relationship of the adherence to the Mediterranean diet with health-related quality of life and treatment satisfaction in patients with type 2 diabetes mellitus: a post-hoc analysis of a cross-sectional study. Health and quality of life outcomes. 2016 ; 14(1):69. doi:10.1186/s12955-016-0473-z. Epub 2016 May 04. pmc:PMC4855697. PMID:27141952. FI: 2,212.

Alcubierre N, Navarrete-Muñoz EM, Rubinat E, Falguera M, Valls J, Traveset A, Vilanova MB, Marsal JR, Hernandez M, Granado-Casas M, Martinez-Gonzalez D, Jurjo C, Franch-Nadal J, Vioque J, Mauricio D. Association of low oleic acid intake with diabetic retinopathy in type 2 diabetic patients: a case-control study. Nutrition & metabolism. 2016 ; 13:40. doi:10.1186/s12986-016-0099-5. Epub 2016 Jun 04. pmc:PMC4893240. PMID:27274760. FI: 3,280.

Alvarado-Cardenas M, Marin-Sánchez A, Martínez MA, Martínez-Martínez L, Pinal-Fernandez I, Labrador-Horrillo M, Balada E, Mundet-Tuduri X, Gonzalez-Mera L, Casademont J, Acebes EM, Moreno PJ, Juarez C, Grau-Junyent JM, Pujol-Borrell R, Selva-O'Callaghan A. Statin-associated autoimmune myopathy: A distinct new IFL pattern can increase the rate of HMGCR antibody detection by clinical laboratories. Autoimmunity reviews. 2016 Dec; 15(12):1161-1166. doi:10.1016/j.autrev.2016.09.005. Epub 2016 Sep 15. PMID:27640317. FI: 8,490.

Alzamora MT, Forés R, Pera G, Baena-Díez JM, Heras A, Sorribes M, Valverde M, Muñoz L, Mundet X, Torán P. Incidence of peripheral arterial disease in the ARTPER population cohort after 5 years of follow-up. BMC cardiovascular disorders. 2016 ; 16:8. doi:10.1186/s12872-015-0170-6. Epub 2016 Jan 12. pmc:PMC4710015. PMID:26758025. FI: 2,021.

Azagra R, Zwart M, Aguyé A, Martín-Sánchez JC, Casado E, Díaz-Herrera MA, Moriña D, Cooper C, Díez-Pérez A, Dennison EM; GROIMAP and FROCAT Study Group. Fracture experience among participants from the FROCAT study: what thresholding is appropriate using the FRAX tool? Maturitas. 2016 Jan;83:65-71. doi: 10.1016/j.maturitas.2015.10.002. Epub 2015 Oct 21. PubMed PMID: 26546077 FI: 3,120.

Baena-Díez JM, Peñafiel J, Subirana I, Ramos R, Elosua R, Marín-Ibañez A, Guembe MJ, Rigo F, Tormo-Díaz MJ, Moreno-Iribas C, Cabré JJ, Segura A, García-Lareo M, Gómez de la Cámara A, Lapetra J, Quesada M, Marrugat J, Medrano MJ, Berjón J, Frontera G, Gavrila D, Barricarte A, Basora J, García JM, Pavone NC, Lora-Pablos D, Mayoral E, Franch J, Mata M, Castell C, Frances A, Grau M; FRESCO Investigators. Risk of Cause-Specific Death in Individuals With Diabetes: A Competing Risks Analysis. Diabetes care. 2016 Nov; 39(11):1987-1995. doi:10.2337/dc16-0614. Epub 2016 Aug 04. PMID:27493134. FI: 8,934.

Barceló MA, Coll-Negre M, Coll-de-Tuero G, Saez M. Effects of the Financial Crisis on Psychotropic Drug Consumption in a Cohort from a Semi-Urban Region in Catalonia, Spain. PloS one. 2016 ; 11(2):e0148594. doi:10.1371/journal.pone.0148594. pii:PONE-D-15-43821. PMID:26872210. FI: 3,057.

Brugnara L, Murillo S, Novials A, Rojo-Martínez G, Soriguer F, Goday A, Calle-Pascual A, Castaño L, Gaztambide S, Valdés S, Franch J, Castell C, Vendrell J, Casamitjana R, Bosch-Comas A, Bordiú E, Carmena R, Catalá M, Delgado E, Girbés J, López-Alba A, Martínez-Larrad MT, Menéndez E, Mora-Peces I, Pascual-Manich G, Serrano-Ríos M, Gomis R, Ortega E. Low Physical Activity and Its Association with Diabetes and Other Cardiovascular Risk Factors: A Nationwide, Population-Based Study. PloS one. 2016 ; 11(8):e0160959. doi:10.1371/journal.pone.0160959. Epub 2016 Zer 17. pmc:PMC4988632. PMID:27532610. FI: 3,057.

Cebrián-Cuenca AM, Orozco-Beltrán D, Navarro-Pérez J, Franch-Nadal J, Núñez-Villota J, Consuegra-Sánchez L. Saxagliptin and risk of heart failure hospitalization: Concern or miscalculation?. International journal of cardiology. 2016 Oct; 220:573-4. doi:10.1016/j.ijcard.2016.06.269. Epub 2016 Zer 29. PMID:27390991. FI: 4,638.

Costa B, Castell C, Cos X, Solé C, Mestre S, Canela M, Boquet A, Cabré JJ, Barrio F, Flores-Mateo G, Ferrer-Vidal D, Lindström J; Catalan Diabetes Prevention Research Group. Rationale and design of the DP-TRANSFERS project: diabetes prevention-transferring findings from European research to society in Catalonia. Journal of translational medicine. 2016 ; 14(1):103. doi:10.1186/s12967-016-0867-z. Epub 2016 Apr 27. pmc:PMC4847192. PMID:27118544. FI: 3,694.

Dòria M, Rosado V, Pacheco LR, Hernández M, Betriu À, Valls J, Franch-Nadal J, Fernández E, Mauricio D. Prevalence of Diabetic Foot Disease in Patients with Diabetes Mellitus under Renal Replacement Therapy in Lleida, Spain. BioMed research international. 2016 ; 2016:7217586. doi:10.1155/2016/7217586. Epub 2016 Zer 14. pmc:PMC4848423. PMID:27190996. FI: 2,134.

Lara B, Cañas F, Vidal A, Nadal N, Rius F, Paredes E, Hernández M, Maravall FJ, Franch-Nadal J, Barbé F, Mauricio D. Knowledge management through two virtual communities of practice (Endobloc and Pneumobloc). Health informatics journal. 2016 Apr; doi:10.1177/1460458216639739. Epub 2016 Apr 21. PMID:27102887. FI: 1,578.

Menéndez E, Delgado E, Fernández-Vega F, Prieto MA, Bordiú E, Calle A, Carmena R, Castaño L, Catalá M, Franch J, Gaztambide S, Girbés J, Goday A, Gomis R, López-Alba A, Martínez-Larrad MT, Mora-Peces I, Ortega E, Rojo-Martínez G, Serrano-Ríos M, Urrutia I, Valdés S, Vázquez JA, Vendrell J, Soriguer F. Prevalence, Diagnosis, Treatment, and Control of Hypertension in Spain. Results of the Di@bet.es Study. Revista espanola de cardiologia (English ed.). 2016 Jun; 69(6):572-8. doi:10.1016/j.rec.2015.11.034. Epub 2016 Mar 12. PMID:26979767.

Muñoz MA, Real J, Del Val JL, Vinyoles E, Mundet X, Frigola-Capell E, Llauger MA, Orfila F, Domingo M, Verdú-Rotellar JM. Determinants of survival and hospitalization in older, heart failure patients receiving home healthcare. International journal of cardiology. 2016 Jan; 207:145-149. doi:10.1016/j.ijcard.2016.01.170. pii:S0167-5273(16)30166-8. PMID:26802820. FI: 4,638.

Orozco-Beltrán D, Mata-Cases M, Artola S, Conthe P, Mediavilla J, Miranda C. Adherence of Type 2 Diabetes Mellitus approach: Current situation and possible solutions. Atencion primaria. 2016 Jun-Jul; 48(6):406-20. doi:10.1016/j.aprim.2015.09.001. Epub 2016 Jan 13. Spanish. PMID:26775266. FI: 1,098.

Paz MA, de-La-Sierra A, Sáez M, Barceló MA, Rodríguez JJ, Castro S, Lagarón C, Garrido JM, Vera P, Coll-de-Tuero G. Treatment efficacy of anti-hypertensive drugs in monotherapy or combination: ATOM systematic review and meta-analysis of randomized clinical trials according to PRISMA statement. Medicine. 2016 Jul; 95(30):e4071. doi:10.1097/MD.0000000000004071. PMID:27472680. FI: 2,133.

Pérez-Orcero A, Vinyoles-Bargalló E, Pujol-Ribera E, de la Figuera-von Wichmann M, Baena-Diez JM, Manjón-Villanueva R, Valiente-Hernandez S, González-Sánchez S, de Diego-Bustillos E, Castelló-Alonso M. Prevalence of orthostatic hypotension in non-institutionalised elderly aged 80 and over. A diagnostic study using an oscillometric device. Hipertension y riesgo vascular. 2016 Jul-Sep; 33(3):93-102. doi:10.1016/j.hipert.2016.02.001. Epub 2016 Mar 26. PMID:27026292.

Riba-Llena I, Nafría C, Filomena J, Tovar JL, Vinyoles E, Mundet X, Jarca CI, Vilar-Bergua A, Montaner J, Delgado P. High daytime and nighttime ambulatory pulse pressure predict poor cognitive function and mild cognitive impairment in hypertensive individuals. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2016 Jan; 36(1):253-63. doi:10.1038/jcbfm.2015.90. pmc:PMC4759685. PMID:25966945. FI: 4,929.

Riba-Llena I, Nafría C, Giralt D, Fernández-Cortiñas I, Jarca CI, Mundet X, Tovar JL, Orfila F, Castañé X, Álvarez-Sabín J, Maisterra O, Montaner J, Delgado P. Dementia Rating Scale-2 normative data for middle-and older-aged Castilian speaking Spaniards. The Clinical neuropsychologist. 2016 May; doi:10.1080/13854046.2016.1174307. Epub 2016 May 11. PMID:27168059. FI: 1,556.

Riba-Llena I, Nafría C, Mundet X, López-Rueda A, Fernández-Cortiñas I, Jarca CI, Jiménez-Balado J, Domingo M, Tovar JL, Orfila F, Pujadas F, Álvarez-Sabín J, Maisterra O, Montaner J, Delgado P. Assessment of enlarged perivascular spaces and their relation to target organ damage and mild cognitive impairment in patients with hypertension. European journal of neurology. 2016 Jun; 23(6):1044-50. doi:10.1111/ene.12979. Epub 2016 Mar 10. PMID:26968973. FI: 3,956.

Sicras-Mainar A, Navarro-Artieda R, Ruiz-Torrejón A, Saez M, Coll-de Tuero G, Sánchez L. A retrospective, observational and multicentre study on patients with hyperactive bladder on treatment with mirabegron and oxybutinine under usual clinical practice conditions. Semergen. 2016 Jun; doi:10.1016/j.semerg.2016.05.006. Epub 2016 Zer 28. PMID:27371430.

Sicras-Mainar A, Navarro-Artieda R, Ruiz-Torrejón A, Sáez-Zafra M, Coll-de Tuero G. Persistence and concomitant medication in patients with overactive bladder treated with antimuscarinic agents in primary care. An observational baseline study. Actas urologicas espanolas. 2016 Mar; 40(2):96-101. doi:10.1016/j.acuro.2015.09.004. Epub 2015 Nov 6. PMID:26556482. FI: 0,667.

Indicators