Research area: Musculoskeletal Diseases

Description

The group resulted from the initiative of general practitioners from the primary care region Barcelona Litoral and Dreta de l’Eixample, in collaboration with the Bone and Joint Pathophysiology Research Unit of the IMIM-Parc de Salut Mar. From 2009 the group collaborates with the Epidemiology Unit of the Orthopaedics, Rheumatology and Musculoskeletal Sciences at the University of Oxford. The group aims to study the risk factors of the most common musculoskeletal disorders (osteoporosis and osteoarthritis) from a primary care perspective and the effectiveness of the treatments currently available.

Research Lines

Epidemiology of the most prevalent musculoskeletal diseases in Primary Health Care: osteoarthritis and osteoporosis, Surgical results according to the patient (patient reported outcomes) referring to hip and knee arthroplasty surgery for osteoarthritis, Epidemiology of other diseases of the locomotor system from the perspective of Primary Health Care, Epidemiology of the adherence to the most used treatments for musculoskeletal diseases, Drug-epidemiology and possible new indications for the most widely used treatments in diseases of the locomotor system.

Members

Projects

The group participates in the following projects:

PI: Prieto Alhambra, Daniel. Non-interventional post-authorization multi-database safety study to further characterize specific safety outcomes in association with use of Entresto® (sacubitril/valsartan) in patients with heart failure. Safety. Funding: Pharmo Institute N.V. Duration: 2017 - 2022

PI: Prieto Alhambra, Daniel. Non-interventional post-authorization multi-database safety study to assess the risk of myotoxicity and hepatotoxicity in statin-exposed heart failure patients with or without concomitant use of LCZ696. Funding: Pharmo Institute N.V. Duration: 2017 - 2020

PI: Prieto Alhambra, Daniel. Drug utilization study of mirabegron (Betmiga®) using real-world healthcare databases from the Netherlands, Spain, United Kingdom and Finland. Funding: Pharmo Institute N.V. Duration: 2017 - 2019

PI: Prieto Alhambra, Daniel. Multinational Observational Database Study on Imminent Osteoporotic Fracture Risk. Funding: University of Oxford. Duration: 2017 - 2019

PI: Prieto Alhambra, Daniel. Impacte del "audit and feedback" de la prevenció quaternària en pacients assignats a equips d'atenció primària a Catalunya del 2009 al 2016. Funding: IDIAP Jordi Gol. Duration: 2017 - 2019

PI: Prieto Alhambra, Daniel. Advanced data analysis and management systems (Big Data solutions) in the identification and assessment of frailty risk profiles in populations, their evolution to disability, and their treatment. Funding: IDIAP Jordi Gol. Duration: 2017 - 2019

PI: Flores Mateo, Gemma. Efectivitat d'una xarxa de voluntaris activats de forma automàtica en la disminució del temps d'inici de les maniobres de Reanimació Cardiopulmonar. Funding: Fundació Acadèmia de les Ciencies Mèdiques. Duration: 2017 - 2018

PI: Prieto Alhambra, Daniel. Secular trends of total knee/hip arthroplasty, related complications, and healthcare resource use in patients with inflammatory arthropathies compared to osteoarthritis: a binational cohort study. Funding: IDIAP Jordi Gol. Duration: 2016 - 2018

PI: Prieto Alhambra, Daniel. Multinational database cohort study to assess RMP specified safety outcomes in association with indacaterol/glycopyrronium bromide in Europe. QVA149A2402. Funding: Synapse Research Management Partners, S.L. Duration: 2014 - 2018

PI: Prieto Alhambra, Daniel. Multinational, multi-database cohort study to assess adverse cardiovascular and cerebrovascular outcomes and mortality in association with inhaled NVA237 in Europe. Funding: Synapse Research Management Partners, S.L. Duration: 2013 - 2018

PI: Cots Yago, Josep M. Seguretat de la discontinuació del tractament antibiòtic quan el metge considera que el pacient no necessita que el segueixi prenent-lo. Estudi STOP-AB. Funding: ICS - Institut Català de la Salut. Duration: 2017

PI: Ramos Blanes, Rafel. Real world Outcomes across the AD spectrum to better care: Multi-modal data Access Platform. Funding: Innovative Medicines Initiative (IMI). Duration: 2016 - 2017

PI: Prieto Alhambra, Daniel. European Program of Post-Authorisation Safety Studies for Protelos®/Osseor® through EU-ADR Alliance. Funding: Synapse Research Management Partners, s.l.. Duration: 2015 - 2017

PI: Prieto Alhambra, Daniel. Efectivitat i seguretat dels tractaments anti-osteoporosi a Catalunya: estudi de cohorts de base poblacional. Funding: IDIAP Jordi Gol. Duration: 2015 - 2017

PI: Bolíbar Ribas, Bonaventura. European Medical Information Framework. Funding: Innovative Medicines Initiative (IMI). Duration: 2015 - 2017

PI: Prieto Alhambra, Daniel. Multinational, multi-database drug utilization study of indacaterol/glycopyrronium bromide in Europe. QVA149A2401. Funding: Synapse Research Management Partners, s.l.. Duration: 2014 - 2017

Publications

The group participates in the following publications:

Bayliss LE, Culliford D, Monk AP, Glyn-Jones S, Prieto-Alhambra D, Judge A, Cooper C, Carr AJ, Arden NK, Beard DJ, Price AJ. The effect of patient age at intervention on risk of implant revision after total replacement of the hip or knee: a population-based cohort study. Lancet (London, England). 2017 Apr; 389(10077):1424-1430. doi:10.1016/S0140-6736(17)30059-4. Epub 2017 Feb 14. pmc:PMC5522532. PMID:28209371. IF: 47,831.

Diez-Perez A, Naylor KE, Abrahamsen B, Agnusdei D, Brandi ML, Cooper C, Dennison E, Eriksen EF, Gold DT, Guañabens N, Hadji P, Hiligsmann M, Horne R, Josse R, Kanis JA, Obermayer-Pietsch B, Prieto-Alhambra D, Reginster JY, Rizzoli R, Silverman S, Zillikens MC, Eastell R; Adherence Working Group of the International Osteoporosis Foundation and the European Calcified Tissue Society. International Osteoporosis Foundation and European Calcified Tissue Society Working Group. Recommendations for the screening of adherence to oral bisphosphonates. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 2017 Mar; 28(3):767-774. doi:10.1007/s00198-017-3906-6. Epub 2017 Jan 16. pmc:PMC5302161. PMID:28093634. IF: 3,591.

Edwards K, Borthwick A, McCulloch L, Redmond A, Pinedo-Villanueva R, Prieto-Alhambra D, Judge A, Arden N, Bowen C. Evidence for current recommendations concerning the management of foot health for people with chronic long-term conditions: a systematic review. Journal of foot and ankle research. 2017 ; 10:51. doi:10.1186/s13047-017-0232-3. Epub 2017 Nov 22. pmc:PMC5700544. PMID:29201147. IF: 1,405.

Eiken PA, Prieto-Alhambra D, Eastell R, Abrahamsen B. Surgically treated osteonecrosis and osteomyelitis of the jaw and oral cavity in patients highly adherent to alendronate treatment: a nationwide user-only cohort study including over 60,000 alendronate users. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 2017 Oct; 28(10):2921-2928. doi:10.1007/s00198-017-4132-y. Epub 2017 Jun 29. PMID:28664276. IF: 3,591.

Francesco L, Elisa B, Raffaella M, Alessandro P, Iacopo C, Giampiero M, Bruno F, Daniel PA, Luisa BM, Claudio C. Assessing Risk of Osteoporotic Fractures in?Primary Care: Development and Validation of the FRA-HS Algorithm. Calcified tissue international. 2017 Jun; 100(6):537-549. doi:10.1007/s00223-016-0230-7. Epub 2017 Feb 03. PMID:28160026. IF: 3,124.

Garcia-Gil M, Reyes C, Ramos R, Sanchez-Santos MT, Prieto-Alhambra D, Spector TD, Hart DJ, Arden NK. Serum Lipid Levels and Risk Of Hand Osteoarthritis: The Chingford Prospective Cohort Study. Scientific reports. 2017 Jun; 7(1):3147. doi:10.1038/s41598-017-03317-4. Epub 2017 Jun 09. pmc:PMC5466681. PMID:28600494. IF: 4,259.

Hawley S, Cordtz R, Dreyer L, Edwards CJ, Arden NK, Delmestri A, Silman A, Cooper C, Judge A, Prieto-Alhambra D. Association between NICE guidance on biologic therapies with rates of hip and knee replacement among rheumatoid arthritis patients in England and Wales: An interrupted time-series analysis. Semin Arthritis Rheum. 2018 Apr;47(5):605-610. doi:10.1016/j.semarthrit.2017.09.006. Epub 2017 Sep 23. PubMed PMID: 29055489; PubMed Central PMCID: PMC5866918. IF: 4,498.

Heintjes EM, Overbeek JA, Hall GC, Prieto-Alhambra D, Lapi F, Hammar N, Bezemer ID. Factors Associated with Type 2 Diabetes Mellitus Treatment Choice Across Four European Countries. Clinical therapeutics. 2017 Nov; 39(11):2296-2310.e14. doi:10.1016/j.clinthera.2017.09.016. Epub 2017 Nov 04. PMID:29108837. IF: 2,947.

Herrera S, Pérez-López J, Moltó-Abad M, Güerri-Fernández R, Cabezudo E, Novelli S, Esteve J, Hernández A, Roig I, Solanich X, Prieto-Alhambra D, Nogués X, Díez-Pérez A. Assessment of Bone Health in Patients With Type 1 Gaucher Disease Using Impact Microindentation. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2017 Jul; 32(7):1575-1581. doi:10.1002/jbmr.3121. Epub 2017 May 11. PMID:28263001. IF: 6,284.

Judge A, Garriga C, Arden NK, Lovestone S, Prieto-Alhambra D, Cooper C, Edwards CJ. Protective effect of antirheumatic drugs on dementia in rheumatoid arthritis patients. Alzheimer's & dementia (New York, N. Y.). 2017 Nov; 3(4):612-621. doi:10.1016/j.trci.2017.10.002. Epub 2017 Nov 09. pmc:PMC5700830. PMID:29201995. IF: 9,478.

Lapi F, Bianchini E, Michieli R, Pasqua A, Cricelli I, Mazzaglia G, Frediani B, Prieto-Alhambra D, Brandi ML, Cricelli C. Erratum to: Assessing risk of osteoporotic fractures in primary care: development and validation of the FRA-HS algorithm. Calcified tissue international. 2017 Jun; 100(6):550. doi:10.1007/s00223-017-0262-7. PMID:28289801. IF: 3,124.

Leal J, Gray AM, Hawley S, Prieto-Alhambra D, Delmestri A, Arden NK, Cooper C, Javaid MK, Judge A; and the REFReSH Study Group. Cost-Effectiveness of Orthogeriatric and Fracture Liaison Service Models of Care for Hip Fracture Patients: A Population-Based Study. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2017 Feb; 32(2):203-211. doi:10.1002/jbmr.2995. Epub 2016 Nov 01. pmc:PMC5321497. PMID:27632945. IF: 6,284.

Losada-Grande E, Hawley S, Soldevila B, Martinez-Laguna D, Nogues X, Diez-Perez A, Puig-Domingo M, Mauricio D, Prieto-Alhambra D. Insulin use and Excess Fracture Risk in Patients with Type 2 Diabetes: A Propensity-Matched cohort analysis. Scientific reports. 2017 Jun; 7(1):3781. doi:10.1038/s41598-017-03748-z. Epub 2017 Jun 19. pmc:PMC5476619. PMID:28630427. IF: 4,259.

Losada-Grande E, Hawley S, Soldevila B, Martinez-Laguna D, Nogues X, Diez-Perez A, Puig-Domingo M, Mauricio D, Prieto-Alhambra D. Insulin use and Excess Fracture Risk in Patients with Type 2 Diabetes: A Propensity-Matched cohort analysis. Scientific reports. 2017 Jun; 7(1):3781. doi:10.1038/s41598-017-03748-z. Epub 2017 Jun 19. pmc:PMC5476619. PMID:28630427. IF: 4,259.

Lübbeke A, Silman AJ, Prieto-Alhambra D, Adler AI, Barea C, Carr AJ. The role of national registries in improving patient safety for hip and knee replacements. BMC musculoskeletal disorders. 2017 Oct; 18(1):414. doi:10.1186/s12891-017-1773-0. Epub 2017 Oct 16. pmc:PMC5644143. PMID:29037237. IF: 1,739.

Martinez-Laguna D, Nogues X, Abrahamsen B, Reyes C, Carbonell-Abella C, Diez-Perez A, Prieto-Alhambra D. Excess of all-cause mortality after a fracture in type 2 diabetic patients: a population-based cohort study. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 2017 Sep; 28(9):2573-2581. doi:10.1007/s00198-017-4096-y. Epub 2017 Jul 25. PMID:28744600. IF: 3,591.

Martinez-Laguna D, Soria-Castro A, Carbonell-Abella C, Orozco-López P, Estrada-Laza P, Nogues X, Díez-Perez A, Prieto-Alhambra D. Validation of fragility fractures in primary care electronic medical records: A population-based study. Reumatol Clin. 2017 Nov 28. pii: S1699-258X(17)30272-3. doi: 10.1016/j.reuma.2017.10.013. [Epub ahead of print] English, Spanish. PubMed PMID: 29195740.

Martín-Merino E, Huerta-Álvarez C, Prieto-Alhambra D, Álvarez-Gutiérrez A, Montero-Corominas D. Secular trends of use of anti-osteoporotic treatments in Spain: A population-based cohort study including over 1.5million people and more than 12years of follow-up. Bone. 2017 Dec; 105:292-298. doi:10.1016/j.bone.2017.08.031. Epub 2017 Sep 08. PMID:28890137. IF: 4,140.

Martín-Merino E, Huerta-Álvarez C, Prieto-Alhambra D, Montero-Corominas D. Cessation rate of anti-osteoporosis treatments and risk factors in Spanish primary care settings: a population-based cohort analysis. Archives of osteoporosis. 2017 Dec; 12(1):39. doi:10.1007/s11657-017-0331-6. Epub 2017 Apr 11. PMID:28401495. IF: 1,960.

Overbeek JA, Heintjes EM, Prieto-Alhambra D, Blin P, Lassalle R, Hall GC, Lapi F, Bianchini E, Hammar N, Bezemer ID, Herings RMC. Type 2 Diabetes Mellitus Treatment Patterns Across Europe: A Population-based Multi-database Study. Clinical therapeutics. 2017 Apr; 39(4):759-770. doi:10.1016/j.clinthera.2017.02.008. Epub 2017 Mar 23. PMID:28342563. IF: 2,947.

Pérez-Sáez MJ, Herrera S, Prieto-Alhambra D, Nogués X, Vera M, Redondo-Pachón D, Mir M, Güerri R, Crespo M, Díez-Pérez A, Pascual J. Bone Density, Microarchitecture, and Tissue Quality Long-term After Kidney Transplant. Transplantation. 2017 Jun; 101(6):1290-1294. doi:10.1097/TP.0000000000001328. PMID:27467533. IF: 3,678.

Pérez-Sáez MJ, Herrera S, Prieto-Alhambra D, Vilaplana L, Nogués X, Vera M, Redondo-Pachón D, Mir M, Güerri R, Crespo M, Díez-Pérez A, Pascual J. Bone density, microarchitecture, and material strength in chronic kidney disease patients at the time of kidney transplantation. Osteoporos Int. 2017 Sep;28(9):2723-2727. doi: 10.1007/s00198-017-4065-5. Epub 2017 May 11. PubMed. PMID: 28497224. IF: 3,591.

Pérez-Sáez MJ, Prieto-Alhambra D, Díez-Pérez A, Pascual J. Advances in the evaluation of bone health in kidney transplant patients. Nefrologia: publicacion oficial de la Sociedad Espanola Nefrologia. 2018 Jan; 38(1):27-33. doi:10.1016/j.nefro.2017.04.002. Epub 2017 Nov 11. PMID:29137893. IF: 1,183.

Reginster JL, Arden NK, Haugen IK, Rannou F, Cavalier E, Bruyère O, Branco J, Chapurlat R, Collaud Basset S, Al-Daghri NM, Dennison EM, Herrero-Beaumont G, Laslop A, Leeb BF, Maggi S, Mkinsi O, Povzun AS, Prieto-Alhambra D, Thomas T, Uebelhart D, Veronese N, Cooper C. Guidelines for the conduct of pharmacological clinical trials in hand osteoarthritis: Consensus of a Working Group of the European Society on Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). Semin Arthritis Rheum. 2017 Dec 7. pii: S0049-0172(17)30462-6. doi: 10.1016/j.semarthrit.2017.12.003. [Epub ahead of print] Review. PubMed PMID: 29287769; PubMed Central PMCID: PMC5907911. IF: 4,498.

Reyes C, Tebe C, Martinez-Laguna D, Ali MS, Soria-Castro A, Carbonell C, Prieto-Alhambra D. One and two-year persistence with different anti-osteoporosis medications: a retrospective cohort study. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 2017 Oct; 28(10):2997-3004. doi:10.1007/s00198-017-4144-7. Epub 2017 Jul 16. PMID:28714038. IF: 3,591.

Roca-Ayats N, Balcells S, Garcia-Giralt N, Falcó-Mascaró M, Martínez-Gil N, Abril JF, Urreizti R, Dopazo J, Quesada-Gómez JM, Nogués X, Mellibovsky L, Prieto-Alhambra D, Dunford JE, Javaid MK, Russell RG, Grinberg D, Díez-Pérez A. GGPS1 Mutation and Atypical Femoral Fractures with Bisphosphonates. The New England journal of medicine. 2017 05; 376(18):1794-1795. doi:10.1056/NEJMc1612804. PMID:28467865. IF: 72,406.

Shah A, Judge A, Delmestri A, Edwards K, Arden NK, Prieto-Alhambra D, Holt TA, Pinedo-Villanueva RA, Hopewell S, Lamb SE, Rangan A, Carr AJ, Collins GS, Rees JL. Incidence of shoulder dislocations in the UK, 1995-2015: a population-based cohort study. BMJ open. 2017 Nov; 7(11):e016112. doi:10.1136/bmjopen-2017-016112. Epub 2017 Nov 14. pmc:PMC5695490. PMID:29138197. IF: 2,369.

Yu D, Jordan KP, Bedson J, Englund M, Blyth F, Turkiewicz A, Prieto-Alhambra D, Peat G. Population trends in the incidence and initial management of osteoarthritis: age-period-cohort analysis of the Clinical Practice Research Datalink, 1992-2013. Rheumatology (Oxford, England). 2017 Nov; 56(11):1902-1917. doi:10.1093/rheumatology/kex270. PMID:28977564. IF: 4,818.

Indicators