Research area: Infectious disease

Description

The primary objective of the group is to define a policy of antibiotics in primary care, in order to achieve a more reasoned prescription of antibiotics in infectious diseases in primary care, identifying the subgroups of patients who really need them. Other objectives are the microbiological aspects of the most prevalent community germs, to diagnose precisely the different infectious processes with the help of rapid diagnostic methods, to better identify whether the aetiology is bacterial or viral and to better understand the level of resistances of common microorganisms. The group is made up of family doctors who work in different lines of research for infectious diseases in primary care. It is planned in the future to also have professionals in the field of microbiology, pneumology, nursing staff and statisticians. This group includes GPs that investigate various aspects of infectious diseases in primary care, together with other professionals such as specialists in respiratory diseases, nurses and statisticians. The group aims to collaborate with microbiology specialists in the near future. GRIP collaborates with the following entities: hospitals (Hospital Vall d'Hebron of Barcelona and Hospital Joan XXIII of Tarragona), universities (Universitat de Barcelona, Universitat Autònoma de Barcelona, Universitat Rovira i Virgili, Cardiff University and University of Copenhagen) and scientific societies (Camfic, SemFYC and WONCA).

Research Lines

Rational use of antibiotics in respiratory tract infections. To know the long-term effectiveness of a multicentric strategy in the use of antibiotics in respiratory infections. To know the effectiveness of an intervention, Infections of the lower respiratory tract: better understanding of subgroups of patients who can benefit from antibiotic treatment and better understanding of the effectiveness of symptomatic treatments in patients with cough. Otitis externa. To know the effectiveness of topical antiseptic treatment compared to oral antibiotic therapy in the resolution of acute otorrea, Acute pharyngitis: knowing the etiology of pharyngitis in adults based on microbiological analysis, effectiveness of the antibiotic treatment, knowing which of the diagnostic strategies help to make a more reasoned use of antibiotics, Urinary tract infections: role of rapid diagnostic methods in the rational use of antibiotics in these infections. Distinguishing urinary tract infections better from urethritis at primary care.

Members

Projects

The group participates in the following projects:

PI: Llor Vilà, Carles. Estudio europeo multicéntrico de enfermedades infecciosas respiratorias: Infecciones Respiratorias Agudas en Adultos. Estudi MERMAIDS. Funding: University of Oxford. Duration: 2017 - 2019

PI: Llor Vilà, Carles. ¿Antivirales para el tratamiento de enfermedades con síntomas gripales? Ensayo clínico aleatorio de la efectividad clínica y económica en Atención Primaria (ALIC4E). Funding: University of Oxford. Duration: 2016 - 2018

PI: Cots Yago, Josep M. Seguretat de la discontinuació del tractament antibiòtic quan el metge considera que el pacient no necessita que el segueixi prenent-lo. Estudi STOP-AB. Funding: ICS - Institut Català de la Salut. Duration: 2017

PI: Llor Vilà, Carles. Avaluació de la validesa del recompte leucocitari en tira reactiva i microscopia en el diagnòstic d’uretritis en persones joves de dos centres de salut. Funding: ICS - Institut Català de la Salut. Duration: 2017

PI: Llor Vilà, Carles. KRISTINA: A Knowledge-Based Information Agent with Social Competence and Human Interaction Capabilities. Funding: European Commission. Duration: 2015 - 2017

PI: Moragas Moreno, Ana. Anàlisi de l'evolució clínica i complicacions de la faringitis aguda en adults i adolescents i associació amb l'etiologia de la infecció. Funding: ICS - Institut Català de la Salut. Duration: 2015 - 2017

Publications

The group participates in the following publications:

Bernardez S, Cots J. Documento de consenso. Recomendaciones de utilización de técnicas de diagnóstico rápido en infecciones respiratorias. Atención Primaria Basada en la Evidencia. 2017;6(5):1-4.

Butler CC, Francis N, Thomas-Jones E, Llor C, Bongard E, Moore M, Little P, Bates J, Lau M, Pickles T, Gal M, Wootton M, Kirby N, Gillespie D, Rumbsy K, Brugman C, Hood K, Verheij T. Variations in presentation, management, and patient outcomes of urinary tract infection: a prospective four-country primary care observational cohort study. The British journal of general practice: the journal of the Royal College of General Practitioners. 2017 Dec; 67(665):e830-e841. doi:10.3399/bjgp17X693641. pmc:PMC5697553. PMID:29158245. IF: 2,760.

Dafa LM, Baudraco CH, Moragas A, Llor C, Molero D, Vilanova P. KRISTINA, un asistente virtual para superar las barreras lingüísticas en la atención sanitaria. Comunidad. 2017;19(2):10.

Hullegie S, Wootton M, Verheij TJM, Thomas-Jones E, Bates J, Hood K, Gal M, Francis NA, Little P, Moore M, Llor C, Pickles T, Gillespie D, Kirby N, Brugman C, Butler CC. Clinicians' interpretations of point of care urine culture versus laboratory culture results: analysis from the four-country POETIC trial of diagnosis of uncomplicated urinary tract infection in primary care. Fam Pract. 2017 Aug 1;34(4):392-399. doi: 10.1093/fampra/cmx009. PubMed PMID: 28334777. IF: 1,804.

Llor C, Alkorta Gurrutxaga M, de la Flor I Bru J, Bernárdez Carracedo S, Cañada Merino JL, Bárcena Caamaño M, Serrano Martino C, Cots Yago JM. Recommendations for the use of rapid diagnosis techniques in respiratory infections in primary care. Atencion primaria. 2017 Aug; 49(7):426-437. doi:10.1016/j.aprim.2017.03.010. Epub 2017 Jun 13. Spanish. PMID:28623011. IF: 1,042.

Llor C, Moragas A, Bayona C, Cots JM, Molero JM, Ribas J, Fóthy JF, Gutiérrez I, Sánchez C, Ortega J, Arranz J, Botanes J, Robles P. The STOP-AB trial protocol: efficacy and safety of discontinuing patient antibiotic treatment when physicians no longer consider it necessary. BMJ open. 2017 Jun; 7(5):e015814. doi:10.1136/bmjopen-2016-015814. Epub 2017 Jun 06. PMID:28592581. IF: 2,369.

Llor C, Moragas A, Cots JM, López-Valcárcel BG; Happy Audit Study Group. Estimated saving of antibiotics in pharyngitis and lower respiratory tract infections if general practitioners used rapid tests and followed guidelines. Atencion primaria. 2017 Jun; 49(6):319-325. doi:10.1016/j.aprim.2016.07.002. Epub 2016 Nov 22. PMID:27884552. IF: 1,042.

Llor C, Moragas A, Hernández S, Crispi S, Cots JM. Misconceptions of Spanish general practitioners attitudes toward the management of urinary tract infections and asymptomatic bacteriuria: an internet-based questionnaire study. Rev Esp Quimioter. 2017;30(5):372-378. PMID:28737026. IF: 0,750.

Llor C, Pérez A, Carandell E, García-Sangenís A, Rezola J, Llorente M, Gestoso S, Bobé F, Román-Rodríguez M, Cots JM, Hernández S, Cortés J, Miravitlles M, Morros R. Efficacy of high doses of penicillin versus amoxicillin in the treatment of uncomplicated community acquired pneumonia in adults. A non-inferiority controlled clinical trial. Aten Primaria. 2017 Oct 20. pii:S0212-6567(17)30234-2. doi: 10.1016/j.aprim.2017.08.003. [Epub ahead of print] PubMed PMID: 29061311. IF: 1,042.

Llor C. Reducing antimicrobial resistance through population empowerment. The European journal of general practice. 2017 Dec; 23(1):51-52. doi:10.1080/13814788.2016.1276166. PMID:28270019. IF: 1,274.

Ramon MA, Esquinas C, Barrecheguren M, Pleguezuelos E, Molina J, Quintano JA, Roman-Rodríguez M, Naberan K, Llor C, Roncero C, Miravitlles M. Self-reported daily walking time in COPD: relationship with relevant clinical and functional characteristics. International journal of chronic obstructive pulmonary disease. 2017 ; 12:1173-1181. doi:10.2147/COPD.S128234. Epub 2017 Apr 13. pmc:PMC5402919. PMID:28458527.

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