Research area: Diabetes

Description

The group is made up of family doctors from the Catalan Health Institute (ICS) with wide experience in the world of diabetes. All of them collaborate with other research groups or scientific societies such as the Spanish Diabetes Society, CAMFiC-SEMFyC, SEMERGEN, or CIBER-DM, and notably in coordination with the group GEDAPS Catalunya and the RedGEDAPS Espanya. It has also collaborated in drawing up the National Health System's diabetes strategy and the Diabetes mellitus type 2 Clinical Practice Guide for the Instituto de Salud Carlos III and the Ministry of Health. The Catalan Advisory Council on Diabetes systematically uses the group's data to prepare its recommendations. The group's main objective is the study of Diabetes mellitus type 2 in primary health care through epidemiological studies based on the exhaustive analysis of the data obtained from e-CAP (electronic clinical records), which will provide demographic and epidemiological information as well as better knowledge of metabolic control, the coexistence of other risk factors, the presence of complications, treatment compliance and therapeutic inertia.

Research Lines

Continuous improvement of the care quality, Determination of cardiovascular risk in people with type 2 DM, Evolution of prediabetes and factors influencing the onset of diabetes, Association between cardiovascular risk factors and the presence of chronic kidney disease in people with type 2 diabetes.

Members

Projects

The group participates in the following projects:

PI: Orfila Pernas, Francesc. Evaluación e intervención multimodal centrada en el paciente anciano en riesgo de resultados adversos, fragilidad y declive funcional en la comunidad. Proyecto CARTS. Funding: Instituto de Salud Carlos III. Duration: 2017 - 2019

PI: Fernández San Martin, Maria Isabel. Efectividad de una intervención grupal psicoeducativa realizada por enfermeras de Atención Primaria en pacientes con depresión y comorbilidad física. Funding: Instituto de Salud Carlos III. Duration: 2017 - 2019

PI: Moreno Martínez, José Antonio. Asociación de diabetes y tuberculosis en un distrito con alta incidencia de tuberculosis. Estudio de casos y controles, 2007-2016. Funding: Instituto de Salud Carlos III. Duration: 2017 - 2019

PI: Mauricio Puente, Dídac. Estudio sobre la adecuación del uso de agonistas del receptor del GLP1 en personas con DM2 en condiciones reales en la Atención Primaria de Cataluña. Estudi CATALONIA. Funding: GlaxoSmithKline, S.A. Duration: 2017 - 2019

PI: Rodriguez Poncelas, Antonio. Asociación entre la administración de inhibidores de la bomba de protocones y la incidencia de enfermedad renal crónica y lesion renal aguda en población general. Funding: IDIAP Jordi Gol. Duration: 2017 - 2019

PI: Mata Cases, José Manuel. Caracterización del riesgo cardiovascular antes del primer evento cardiovascular a una edad prematura en Cataluña. Funding: IDIAP Jordi Gol. Duration: 2017 - 2019

PI: Mata Cases, José Manuel. Caracterización del riesgo cardiovascular antes del primer evento cardiovascular prematuro en Catalunya. Funding: Departament de Salut. Duration: 2017 - 2019

PI: Franch Nadal, Josep. Incidència de la diabetis tipus 2 a Catalunya (estudi di@bet.es II .cat). Funding: Departament de Salut. Duration: 2017 - 2019

PI: Franch Nadal, Josep. Patient characteristics and cardiovascular and mortality outcomes in patients with high cardiovascular risk and type 2 diabetes mellitus initiating treatment with sodium-glucose co-transporter-2 inhibitors and other antidiabetic medications. Funding: AstraZeneca Farmacéutica Spain, S.A. Duration: 2017 - 2019

PI: Mata Cases, José Manuel. Global and country-specific rates and trends in the incidence of diagnosed type 2 diabetes (GLOBALDIAB). Duration: 2017 - 2019

PI: Verdú Rotellar, José María. Estratificación pronóstica de la insuficiencia cardiaca descompensada en atención primaria: Estudio HEFESTOS. Funding: Instituto de Salud Carlos III. Duration: 2015 - 2019

PI: Pedrós Cholvi, Consuelo. Riesgo de acidosis láctica asociado al uso de metformina en pacientes diabéticos tipo 2 con enfermedad renal crónica moderada-severa: estudio de casos y controles. Funding: Inst. d'Investigació Biomèdica de Bellvitge (IDIBELL). Duration: 2017 - 2018

PI: Cerezo Goyeneche, Carlos. Ensayo híbrido de evaluación de una intervención compleja multiriesgo para promover conductas saludables en personas de 45-75 años atendidas en Atención Primaria: estudio EIRA3. Subproyecto Girona. Funding: Instituto de Salud Carlos III. Duration: 2016 - 2018

PI: Clua Espuny, Josep Lluis. Atrial Fibrillation Research in CATalonia (AFRICAT): sequential clinicelectro-biological screening among high risk individuals. Funding: Fundacio La Marato de TV3. Duration: 2016 - 2018

PI: Coll de Tuero, Gabriel. Comportamiento dinámico del síndrome metabólico y elaboración de una ecuación para predecir el riesgo cardiovascular en los pacientes con Diabetes tipo 2 de una cohorte retrospectiva obtenida a partir de una base de datos clínico administrativa. Funding: Instituto de Salud Carlos III. Duration: 2016 - 2018

PI: Mata Cases, José Manuel. COSMODIA (COSt analysis using the Core Diabetes MOdel in Type 2 DIAbetes) Análisis de los datos del Estudio eCostesDM (costes de la atención al paciente con DM2 en Catalunya) mediante la aplicación de un modelo matemático (Core Diabetes Model) en colaboración con el York Health Economics Consortium de la Universitat de YorkDuration: 2016 - 2018i>

PI: Mauricio Puente, Dídac. Estudio transversal para analizar la epidemiología de la DM1 con la base de datos SIDIAP. eControl epiDM1. Funding: Lilly, S.A. Duration: 2016 - 2018

PI: Mata Cases, José Manuel. Prevalence of comorbidities among type 2 diabetes mellitus (T2DM) patients in Spain. Funding: Merck Sharp & Dohme de España, S.A. Duration: 2016 - 2018

PI: Molló Iniesta, M.Angels. Estudio INTEGRA: estrategia de INTervención intEgral en pacientes con mal control Glucémico de la diabetes mellitus tipo 2 en el Ámbito de Atención PRimariA. Funding: Sanofi Aventis, S.A. Duration: 2014 - 2018

PI: Romaguera Bosch, Montserrat. Screening Physical Activity in Family Practice: Validity of the Spanish Version of a Brief Physical Activity Questionnaire. Funding: Colegi oficial de metges de Barcelona. Duration: 2017

PI: Delgado Martínez, Maria Pilar. Influencia del tipo de tratamiento antihipertensivo prescrito en la práctica clínica habitual sobre la variabilidad de la presión arterial y el riesgo cardiovascular del hipertenso. Funding: Instituto de Salud Carlos III. Duration: 2015 - 2017

PI: Muñoz Pérez, Miguel Angel. Factores pronósticos de mortalidad a corto plazo en enfermos con Insuficiencia cardiaca avanzada: Estudio HADES. Funding: IDIAP Jordi Gol. Duration: 2015 - 2017

PI: Mata Cases, José Manuel. Inercia terapéutica en los pacientes con Diabetes tipo 2 tratados con dos o más antidiabéticos no insulínicos seguidos durante 7 años en un registro poblacional. Funding: Sanofi Aventis, S.A. Duration: 2015 - 2017

Publications

The group participates in the following publications:

Alvarado-Martel D, Ruiz Fernández MA, Cuadrado Vigaray M, Carrillo A, Boronat M, Expósito Montesdeoca A, Nattero Chávez L, Pozuelo Sánchez M, López Quevedo P, Santana Suárez AD, Hillman N, Subias D, Martin Vaquero P, Sáez de Ibarra L, Mauricio D, de Pablos-Velasco P, Nóvoa FJ, Wägner AM. ViDa1: The Development and Validation of a New Questionnaire for Measuring Health-Related Quality of Life in Patients with Type 1 Diabetes. Frontiers in psychology. 2017 ; 8:904. doi:10.3389/fpsyg.2017.00904. Epub 2017 May 31. pmc:PMC5450776. PMID:28620331. IF: 2,323.

Arcidiacono MV, Martinez-Alonso M, Belart M, Vilar A, Martín M, Craver L, Betriu À, Mauricio D, Valdivielso JM, Fernández E, Borràs M. High Levels of Hemoglobin Promote Carotid Adventitial Vasa Vasorum Neoangiogenesis in Chronic Kidney Disease. Mediators Inflamm. 2017;2017:3795142. doi: 10.1155/2017/3795142. Epub 2017 Jan 4. PubMed PMID: 28133420; PubMed Central PMCID: PMC5241472. IF: 3,232.

Barceló MA, Rodríguez-Poncelas A, Saez M, Coll-de-Tuero G. The dynamic behaviour of metabolic syndrome and its components in an eight-year population-based cohort from the Mediterranean. PloS one. 2017 ; 12(5):e0176665. doi:10.1371/journal.pone.0176665. Epub 2017 May 18. pmc:PMC5436648. PMID:28545089. IF: 2,806.

Castelblanco E, Zafon C, Maravall J, Gallel P, Martinez M, Capel I, Bella MR, Halperin I, Temprana J, Iglesias C, Puig-Domingo M, Robledo M, Matias-Guiu X, Mauricio D. APLP2, RRM2, and PRC1: New Putative Markers for the Differential Diagnosis of Thyroid Follicular Lesions. Thyroid : official journal of the American Thyroid Association. 2017 Jan; 27(1):59-66. doi:10.1089/thy.2016.0094. Epub 2016 Nov 30. PMID:27796194. IF: 5,515.

Català Tella N, Serna Arnaiz C, Real Gatius J, Yuguero Torres O, Galván Santiago L. Assessment of the length of sick leave in patients with ischemic heart disease. BMC cardiovascular disorders. 2017 Jan; 17(1):32. doi:10.1186/s12872-016-0460-7. Epub 2017 Jan 18. pmc:PMC5242005. PMID:28100195. IF: 2,021.

Comin E, Catalan-Ramos A, Iglesias-Rodal M, Grau M, Del Val JL, Consola A, Amado E, Pons A, Mata-Cases M, Franzi A, Ciurana R, Frigola E, Cos X, Davins J, Verdu-Rotellar JM. Impact of implementing electronic clinical practice guidelines for the diagnosis, control and treatment of cardiovascular risk factors: A pre-post controlled study. Atencion primaria. 2017 Aug; 49(7):389-398. doi:10.1016/j.aprim.2016.11.007. Epub 2017 Mar 15. PMID:28314542. IF: 1,042.

Cruz-Esteve I, Marsal-Mora JR, Galindo-Ortego G, Galván-Santiago L, Serrano-Godoy M, Ribes-Murillo E, Real-Gatius J; en representaci?n del grupo de investigaci?n GRETAP. Potentially inappropriate prescribing in older Spanish population according to STOPP/START criteria (STARTREC study). Atencion primaria. 2017 Mar; 49(3):166-176. doi:10.1016/j.aprim.2016.02.013. Epub 2016 Sep 29. Spanish. PMID:27693033. IF: 1,042.

Cuervo Pinto R, Álvarez-Rodríguez E, González Pérez de Villar N, Artola-Menéndez S, Girbés Borrás J, Mata-Cases M, Galindo Rubio M, Puig Larrosa J, Muñoz Albert R, Díaz Pérez JÁ. [Managing the discharge of diabetic patients from the emergency department: a consensus paper]. Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias. 2017 Oct; 29(5):343-351. Spanish. PMID:29077295. IF: 3,028.

Forés R, Alzamora M, Pera G, Valverde M, Baena J, Mundet X. Evolution and degree of control of cardiovascular risk factors after 5 years of follow-up and their relationship with the incidence of peripheral arterial disease: ARTPER cohort. Med Clin (Barc). 2017;148(3):107-113. PMID:27894602. IF: 1,125.

Formiga F, Franch-Nadal J, Rodriguez L, Ávila L, Fuster E. Inadequate Glycaemic Control and Therapeutic Management of Adults over 65 Years Old with Type 2 Diabetes Mellitus in Spain. The journal of nutrition, health & aging. 2017 ; 21(10):1365-1370. doi:10.1007/s12603-017-0869-4. PMID:29188902. IF: 2,772.

Franch-Nadal J, Mediavilla-Bravo J, Mata-Cases M, Mauricio D, Asensio D, Sarroca J. Prevalence and control of type 2 diabetes mellitus among primary care physicians in Spain. PRISMA Study. Endocrinologia, diabetes y nutricion. 2017 May; 64(5):265-271. doi:10.1016/j.endinu.2017.03.003. Epub 2017 Apr 27. PMID:28495322.

Gomis R, Mata Cases M, Mauricio Puente D, Artola Menéndez S, Ena Muñoz J, Mediavilla Bravo JJ, Miranda Fernández-Santos C, Orozco Beltrán D, Rodríguez Mañas L, Sánchez Villalba C, Martínez JA. Methodological aspects of integrated care pathways. Revista de calidad asistencial : organo de la Sociedad Espanola de Calidad Asistencial. 2017 Jul; 32(4):234-239. doi:10.1016/j.cali.2016.12.003. Epub 2017 Mar 07. Spanish. PMID:28283260.

Granado-Casas M, Martínez-Alonso M, Alcubierre N, Ramírez-Morros A, Hernández M, Castelblanco E, Torres-Puiggros J, Mauricio D. Decreased quality of life and treatment satisfaction in patients with latent autoimmune diabetes of the adult. PeerJ. 2017 ; 5:e3928. doi:10.7717/peerj.3928. Epub 2017 Oct 18. pmc:PMC5650726. PMID:29062603. IF: 2,177.

Hernández M, López C, Real J, Valls J, Ortega-Martinez de Victoria E, Vázquez F, Rubinat E, Granado-Casas M, Alonso N, Molí T, Betriu A, Lecube A, Fernández E, Leslie RD, Mauricio D. Preclinical carotid atherosclerosis in patients with latent autoimmune diabetes in adults (LADA), type 2 diabetes and classical type 1 diabetes. Cardiovascular diabetology. 2017 Jul; 16(1):94. doi:10.1186/s12933-017-0576-9. Epub 2017 Jul 28. pmc:PMC5532780. PMID:28750634. IF: 4,752.

Lara B, Cañas F, Vidal A, Nadal N, Rius F, Paredes E, Hernández M, Maravall FJ, Franch-Nadal J, Barbé F, Mauricio D. Knowledge management through two virtual communities of practice (Endobloc and Pneumobloc). Health informatics journal. 2017 Sep; 23(3):170-180. doi:10.1177/1460458216639739. Epub 2016 Apr 21. PMID:27102887. IF: 3,021.

López-Simarro F, Moral I, Aguado-Jodar A, Cols-Sagarra C, Mancera-Romero J, Alonso-Fernández M, Miravet-Jiménez S, Brotons C. The impact of therapeutic inertia and the degree of the medication adherence on the control goals for patients with diabetes. Semergen. 2017 Nov 21. pii: S1138-3593(17)30301-5. doi: 10.1016/j.semerg.2017.10.002. [Epub ahead of print] Spanish. PubMed PMID:29174068. Losada-Grande E, Hawley S, Soldevila B, Martinez-Laguna D, Nogues X, Diez-Perez A, Puig-Domingo M, Mauricio D, Prieto-Alhambra D. Insulin use and Excess Fracture Risk in Patients with Type 2 Diabetes: A Propensity-Matched cohort analysis. Scientific reports. 2017 Jun; 7(1):3781. doi:10.1038/s41598-017-03748-z. Epub 2017 Jun 19. pmc:PMC5476619. PMID:28630427. IF: 4,259.

Losada-Grande E, Hawley S, Soldevila B, Martinez-Laguna D, Nogues X, Diez-Perez A, Puig-Domingo M, Mauricio D, Prieto-Alhambra D. Insulin use and Excess Fracture Risk in Patients with Type 2 Diabetes: A Propensity-Matched cohort analysis. Scientific reports. 2017 Jun; 7(1):3781. doi:10.1038/s41598-017-03748-z. Epub 2017 Jun 19. pmc:PMC5476619. PMID:28630427. IF: 4,259.

Marti J, López F, Gascón I, Julve J. Propolis nasal spray effectively improves recovery from infectious acute rhinitis and common cold symptoms in children: a pilot study. Journal of biological regulators and homeostatic agents. 2017 Oct-Dec; 31(4):943-950. PMID:29254297. IF: 1,469.

Mata-Cases M, Mauricio D, Franch-Nadal J. Clinical characteristics of type 2 diabetic patients on basal insulin therapy with adequate fasting glucose control who do not achieve HbA1c targets. Journal of diabetes. 2017 Jan; 9(1):34-44. doi:10.1111/1753-0407.12373. Epub 2016 Feb 24. PMID:26749415. IF: 3,039.

Mauricio D, Meneghini L, Seufert J, Liao L, Wang H, Tong L, Cali A, Stella P, Carita P, Khunti K. Glycaemic control and hypoglycaemia burden in patients with type 2 diabetes initiating basal insulin in Europe and the USA. Diabetes, obesity & metabolism. 2017 Aug; 19(8):1155-1164. doi:10.1111/dom.12927. Epub 2017 Apr 10. pmc:PMC5573947. PMID:28251792. IF: 6,715.

Mishra R, Chesi A, Cousminer DL, Hawa MI, Bradfield JP, Hodge KM, Guy VC, Hakonarson H, , Mauricio D, Schloot NC, Yderstræde KB, Voight BF, Schwartz S, Boehm BO, Leslie RD, Grant SFA; Bone Mineral Density in Childhood Study. Relative contribution of type 1 and type 2 diabetes loci to the genetic etiology of adult-onset, non-insulin-requiring autoimmune diabetes. BMC medicine. 2017 04; 15(1):88. doi:10.1186/s12916-017-0846-0. Epub 2017 Apr 25. pmc:PMC5404312. PMID:28438156. IF: 7,901.

Mundet-Tuduri X, Crespo R, Fernandez-Coll ML, Saumell M, Millan-Mata F, Cardona À, Codern-Bové N. Expectations and perceptions of primary healthcare professionals regarding their own continuous education in Catalonia (Spain): a qualitative study. BMC medical education. 2017 Nov; 17(1):212. doi:10.1186/s12909-017-1061-6. Epub 2017 Nov 15. pmc:PMC5688635. PMID:29141621.

Muñoz MA, Mundet-Tuduri X, Real J, Del Val JL, Domingo M, Vinyoles E, Calero E, Checa C, Soldevila-Bacardit N, Verdú-Rotellar JM. Heart failure labelled patients with missing ejection fraction in primary care: prognosis and determinants. BMC family practice. 2017 Mar; 18(1):38. doi:10.1186/s12875-017-0612-6. Epub 2017 Mar 17. PMID:28302060. IF: 1,751.

Pickwell K, Siersma V, Kars M, Apelqvist J, Bakker K, Edmonds M, Holstein P, Jirkovská A, Jude EB, Mauricio D, Piaggesi A, Reike H, Spraul M, Uccioli L, Urbancic V, van Acker K, van Baal J, Schaper N. Minor amputation does not negatively affect health-related quality of life as compared with conservative treatment in patients with a diabetic foot ulcer: An observational study. Diabetes/metabolism research and reviews. 2017 03; 33(3). doi:10.1002/dmrr.2867. Epub 2016 Nov 30. PMID:27792855.

Ramírez-Morros A, Granado-Casas M, Alcubierre N, Martinez-Alonso M, Real J, Castelblanco E, Esquerda A, Cao G, Rubinat E, Hernández M, Alonso N, Fernández E, Mauricio D. Calcium Phosphate Product Is Associated with Subclinical Carotid Atherosclerosis in Type 2 Diabetes. J Diabetes Res. 2017;2017:3498368. doi:10.1155/2017/3498368. Epub 2017 Aug 3. PubMed PMID: 28840128; PubMed Central PMCID: PMC5559910. IF: 2,717.

Serra-Planas E, Aguilera E, Castro L, Rodríguez R, Salinas I, Lucas A, Joaquín C, Puig R, Mauricio D, Puig-Domingo M. Low prevalence of non-alcoholic fatty liver disease in patients with type 1 diabetes is associated with decreased subclinical cardiovascular disease. Journal of diabetes. 2017 Dec; 9(12):1065-1072. doi:10.1111/1753-0407.12539. Epub 2017 May 29. PMID:28220621. IF: 3,039.

Siersma V, Thorsen H, Holstein PE, Kars M, Apelqvist J, Jude EB, Piaggesi A, Bakker K, Edmonds M, Jirkovská A, Mauricio D, Reike H, Spraul M, Uccioli L, Urbancic V, van Acker K, van Baal J, Schaper NC. Diabetic complications do not hamper improvement of health-related quality of life over the course of treatment of diabetic foot ulcers - the Eurodiale study. Journal of diabetes and its complications. 2017 Jul; 31(7):1145-1151. doi:10.1016/j.jdiacomp.2017.04.008. Epub 2017 Apr 13. PMID:28457703. IF: 2,734.

Valdés S, Maldonado-Araque C, Lago-Sampedro A, Lillo JA, Garcia-Fuentes E, Perez-Valero V, Gutierrez-Repiso C, Ocon-Sanchez P, Goday A, Urrutia I, Peláez L, Calle-Pascual A, Bordiú E, Castaño L, Castell C, Delgado E, Menendez E, Franch J, Gaztambide S, Girbés J, Ortega E, Lopez-Alba A, Chaves FJ, Vendrell J, Chacón MR, Soriguer F, Rojo-Martínez G. Population-Based National Prevalence of Thyroid Dysfunction in Spain and Associated Factors: Di@bet.es Study. Thyroid : official journal of the American Thyroid Association. 2017 Feb; 27(2):156-166. doi:10.1089/thy.2016.0353. Epub 2017 Jan 04. PMID:27835928. IF: 5,515.

Valdés S, Maldonado-Araque C, Lago-Sampedro A, Lillo-Muñoz JA, Garcia-Fuentes E, Perez-Valero V, Gutiérrez-Repiso C, Garcia-Escobar E, Goday A, Urrutia I, Peláez L, Calle-Pascual A, Bordiú E, Castaño L, Castell C, Delgado E, Menéndez E, Franch-Nadal J, Gaztambide S, Girbés J, Ortega E, Vendrell J, Chacón MR, Javier Chaves F, Soriguer F, Rojo-Martínez G. Reference values for TSH may be inadequate to define hypothyroidism in persons with morbid obesity: Di@bet.es study. Obesity (Silver Spring). 2017 Apr;25(4):788-793. doi: 10.1002/oby.21796. Epub 2017 Mar 9. PubMed PMID: 28276648. IF: 3,873.

Vilanova MB, Falguera M, Marsal JR, Rubinat E, Alcubierre N, Catelblanco E, Granado-Casas M, Miró N, Molló À, Mata-Cases M, Franch-Nadal J, Mauricio D. Prevalence, clinical features and risk assessment of pre-diabetes in Spain: the prospective Mollerussa cohort study. BMJ open. 2017 Jun; 7(6):e015158. doi:10.1136/bmjopen-2016-015158. Epub 2017 Jun 11. PMID:28606902. IF: 2,369.

Awards

Best papers published in Revista Científica de la Sociedad Española de Diabetes. ¿Se registra y clasifica correctamente la diabetes mellitus en atención primaria? Estudio poblacional en Cataluña, España. Mata J, Mauricio D, Real J, Bolíbar B, Franch J.

Indicators