Research area: Cardiovascular

Description

The ISV group is fully integrated in the cardiovascular area of the IDIAP since the main researcher of the group is, in turn, the area coordinator. He has participated with great involvement in the cardiovascular group of the AIAPP network through the leadership of the CARDIOCAT group (the seven members of the ISV group belong to CARDIOCAT and its IP also belongs to the CARDIOCAT). On the other hand, it is also present through its PI (which performs the tasks of coordinator) in the vascular prevention group of the Vascular Diseases Plan of the Department of Health of the Generalitat de Catalunya. The members of the ISV belong to different areas of the Primary Health care system, including management, teaching, patient care and research. The central research objective of the group is to improve the detection and management of patients with intermediate cardiovascular risk, the detection of CV disease in the asymptomatic phase and to analyze the cost effectiveness of interventions for the prevention of cardiovascular disease.

Research Lines

The evaluation of preventive interventions that include the impact of risk estimation strategies in clinical practice and the study of the efficacy of drugs used in the primary prevention of cardiovascular diseases, Epidemiology of vascular diseases and their risk factors. Asymptomatic disease and the role that early detection can have in prediction and prevention., Mathematical models of risk prediction: creation of tools that allow the transfer of epidemiological knowledge in clinical practice including the design of tools to support decision making process.

Members

Projects

The group participates in the following projects:

PI: Garcia Gil, Mª del Mar. Efectividad de los Objetivos Terapéuticos de la Lipoproteina de Baja Densidad (cLDL) en la Reducción de Eventos Aterotrombóticos. Proyecto ELECTRA. Funding: Instituto de Salud Carlos III. Duration: 2017 - 2019

PI: Rodriguez Poncelas, Antonio. Asociación entre la administración de inhibidores de la bomba de protocones y la incidencia de enfermedad renal crónica y lesion renal aguda en población general. Funding: IDIAP Jordi Gol. Duration: 2017 - 2019

PI: Elosua Llanos, Roberto. Seguiment de la cohort poblacional de l'estudi REGICOR: tendències en la incidència de malaltia cardiovascular, en la prevalença de factors de risc, identificació de nous mecanismes i biomarcadors predictius, i avaluació d'estratègies de prevenció.. Funding: Fundació IMIM (Fundació Institut Mar d'Investigacions Mèdiques). Duration: 2017 - 2019

PI: Ramos Blanes, Rafel. Epidemiologia de la Hipercolesterolèmia Familiar; predicció de risc, efectivitat i seguretat del tractament hipolipemiant. Funding: Departament de Salut. Duration: 2017 - 2019

PI: Garcia Gil, Mª del Mar. Validació dels diagnòstics de cardiopatia isquèmica a SIDIAP. Funding: IDIAP Jordi Gol. Duration: 2017 - 2018

PI: Cerezo Goyeneche, Carlos. Ensayo híbrido de evaluación de una intervención compleja multiriesgo para promover conductas saludables en personas de 45-75 años atendidas en Atención Primaria: estudio EIRA3. Subproyecto Girona. Funding: Instituto de Salud Carlos III. Duration: 2016 - 2018

PI: Ponjoan Thans, Anna. Factores de riesgo de demencia y mortalidad tras el diagnóstico de demencia. Funding: Fund. Priv. Inst. Inv. Biomèdica Girona Dr. Josep Trueta. Duration: 2016 - 2018

PI: Duarte Salles, Talita. Validació dels diagnòstics de càncer al SIDIAP a través de la seva vinculació amb les dades del Registre de Càncer de Girona. Funding: IDIAP Jordi Gol. Duration: 2017

PI: Ramos Blanes, Rafel. Real world Outcomes across the AD spectrum to better care: Multi-modal data Access Platform. Funding: Innovative Medicines Initiative (IMI). Duration: 2016 - 2017

PI: Morros Pedrós, Rosa. Impact of adherence to the pollypill components o mortality and cardiovascular morbidity: a population-based, retrospective database study. Funding: Ferrer Internacional, S.A. Duration: 2015 - 2017

PI: Nieuwenhuijsen -, Mark. Green Space and Mortality. Funding: Centre de Recerca en Epidemiologia Ambiental (CREAL). Duration: 2015 - 2017

PI: Ponjoan Thans, Anna. Association between sudden changes in ambient temperature and cardiovascular hospitalisations or mortality: a population study from Catalonia (SURIA Study). Funding: IDIAP Jordi Gol. Duration: 2015 - 2017

PI: Bolíbar Ribas, Bonaventura. European Medical Information Framework. Funding: Innovative Medicines Initiative (IMI). Duration: 2015 - 2017

Publications

The group participates in the following publications:

NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128?9 million children, adolescents, and adults. Lancet (London, England). 2017 Oct; doi:10.1016/S0140-6736(17)32129-3. Epub 2017 Oct 10. PMID:29029897. IF: 47,831.

Alves-Cabratosa L, García-Gil M, Comas-Cufí M, Ponjoan A, Martí-Lluch R, Parramon D, Blanch J, Elosua-Bayes M, Ramos R. Statins and new-onset atrial fibrillation in a cohort of patients with hypertension. Analysis of electronic health records, 2006-2015. PLoS One. 2017 Oct 26;12(10):e0186972. doi:10.1371/journal.pone.0186972. eCollection 2017. PubMed PMID: 29073212; PubMedCentral PMCID: PMC5658105. IF: 2,806.

Buron A, Auge JM, Sala M, Román M, Castells A, Macià F, Comas M, Guiriguet C, Bessa X, Castells X; and the PROCOLON research group. Association between socioeconomic deprivation and colorectal cancer screening outcomes: Low uptake rates among the most and least deprived people. PloS one. 2017 ; 12(6):e0179864. doi:10.1371/journal.pone.0179864. Epub 2017 Jun 16. pmc:PMC5473580. PMID:28622365. IF: 2,806.

Comas M, Vila A, Garcia M, Alves L, Ramos R. Familial hypercholesterolemia in a European Mediterranean population-Prevalence and clinical data from 2.5 million primary care patients. J Clin Lipidol. 2017;11(4):1013-1022. PMID:28826564. IF: 5,812.

Dégano IR, Marrugat J, Grau M, Salvador-González B, Ramos R, Zamora A, Martí R, Elosua R. The association between education and cardiovascular disease incidence is mediated by hypertension, diabetes, and body mass index. Scientific reports. 2017 Sep; 7(1):12370. doi:10.1038/s41598-017-10775-3. Epub 2017 Sep 28. pmc:PMC5620039. PMID:28959022. IF: 4,259.

Dégano IR, Marrugat J, Grau M, Salvador-González B, Ramos R, Zamora A, Martí R, Elosua R. The association between education and cardiovascular disease incidence is mediated by hypertension, diabetes, and body mass index. Scientific reports. 2017 Sep; 7(1):12370. doi:10.1038/s41598-017-10775-3. Epub 2017 Sep 28. pmc:PMC5620039. PMID:28959022. IF: 4,259.

Galván I, Jorge A, García-Gil M. Pheomelanin molecular vibration is associated with mitochondrial ROS production in melanocytes and systemic oxidative stress and damage. Integrative biology : quantitative biosciences from nano to macro. 2017 Sep; 9(9):751-761. doi:10.1039/c7ib00107j. PMID:28726920. IF: 3,252.

Garcia-Gil M, Comas-Cufí M, Blanch J, Martí R, Ponjoan A, Alves-Cabratosa L, Petersen I, Marrugat J, Elosua R, Grau M, Ramos R. Effectiveness of Statins as Primary Prevention in People With Different Cardiovascular Risk: A Population-Based Cohort Study. Clin Pharmacol Ther. 2017 Dec 1. doi: 10.1002/cpt.954. [Epub ahead of print] PubMed PMID: 29194590. IF: 7,266.

Garcia-Gil M, Reyes C, Ramos R, Sanchez-Santos MT, Prieto-Alhambra D, Spector TD, Hart DJ, Arden NK. Serum Lipid Levels and Risk Of Hand Osteoarthritis: The Chingford Prospective Cohort Study. Scientific reports. 2017 Jun; 7(1):3147. doi:10.1038/s41598-017-03317-4. Epub 2017 Jun 09. pmc:PMC5466681. PMID:28600494. IF: 4,259.

Gomez-Sanchez L, Garcia-Ortiz L, Patino-Alonso MC, Recio-Rodriguez JI, Feuerbach N, Marti R, Agudo-Conde C, Rodriguez-Sanchez E, Maderuelo-Fernandez JA, Ramos R, Gomez-Marcos MA; MARK Group. Glycemic markers and relation with arterial stiffness in Caucasian subjects of the MARK study. PloS one. 2017 ; 12(4):e0175982. doi:10.1371/journal.pone.0175982. Epub 2017 Apr 17. pmc:PMC5393622. PMID:28414819. IF: 2,806.

Gomez-Sanchez L, Garcia-Ortiz L, Patino-Alonso MC, Recio-Rodriguez JI, Rigo F, Martí R, Agudo-Conde C, Rodriguez-Sanchez E, Maderuelo-Fernandez JA, Ramos R, Gomez-Marcos MA; MARK Group. Adiposity measures and arterial stiffness in primary care: the MARK prospective observational study. BMJ open. 2017 Sep; 7(9):e016422. doi:10.1136/bmjopen-2017-016422. Epub 2017 Sep 27. pmc:PMC5623460. PMID:28963288. IF: 2,369.

Martí-Lluch R, Garcia-Gil MDM, Camós L, Comas-Cufí M, Elosua-Bayés M, Blanch J, Ponjoan A, Alves-Cabratosa L, Elosua R, Grau M, Marrugat J, Ramos R. Differences in cardio-ankle vascular index in a general Mediterranean population depending on the presence or absence of metabolic cardiovascular risk factors. Atherosclerosis. 2017 Jul; 264:29-35. doi:10.1016/j.atherosclerosis.2017.07.013. Epub 2017 Jul 13. PMID:28756313. IF: 4,239.

Massó-van Roessel A, Escobar-Robledo LA, Dégano IR, Grau M, Sala J, Ramos R, Marrugat J, Bayés de Luna A, Elosua R. Analysis of the Association Between Electrocardiographic P-wave Characteristics and Atrial Fibrillation in the REGICOR Study. Rev Esp Cardiol (Engl Ed). 2017 Oct;70(10):841-847. doi: 10.1016/j.rec.2017.02.019. Epub 2017 Mar 18. English, Spanish. PubMed PMID:28330820. IF: 4,485.

Ponjoan A, Blanch J, Alves L, Martí R, Comas M, Parramon D, Garcia MD, Ramos R, Petersen I. Effects of extreme temperatures on cardiovascular emergency hospitalizations in a Mediterranean region: a self-controlled case series study. Environ Health. 2017;16(1):32-32. PMID:28376798. IF: 3,816.

Recio-Rodriguez JI, Garcia-Yu IA, Alonso-Dominguez R, Maderuelo-Fernandez JA, Patino-Alonso MC, Agudo-Conde C, Sanchez-Aguadero N, Ramos R, Marti R, Rodriguez-Sanchez E, Gómez-Marcos MA, Garcia-Ortiz L. Diet quality and carotid atherosclerosis in intermediate cardiovascular risk individuals. Nutrition journal. 2017 Jul; 16(1):40. doi:10.1186/s12937-017-0266-1. Epub 2017 Jul 03. pmc:PMC5494789. PMID:28673286. IF: 2,597.

Vázquez-Oliva G, Zamora A, Ramos R, Marti R, Subirana I, Grau M, Dégano IR, Marrugat J, Elosua R. Acute Myocardial Infarction Population Incidence and Mortality Rates, and 28-day Case-fatality in Older Adults. The REGICOR Study. Rev Esp Cardiol (Engl Ed). 2017 Nov 22. pii: S1885-5857(17)30486-3. doi: 10.1016/j.rec.2017.10.019. [Epub ahead of print] English, Spanish. PubMed PMID:29174866. IF: 4,485.

Velescu A, Clara A, Martí R, Ramos R, Perez-Fernandez S, Marcos L, Grau M, Degano IR, Marrugat J, Elosua R. Abnormally High Ankle-Brachial Index is Associated with All-cause and Cardiovascular Mortality: The REGICOR Study. Eur J Vasc Endovasc Surg. 2017 Sep;54(3):370-377. doi: 10.1016/j.ejvs.2017.06.002. Epub 2017 Jul 25. PubMed PMID: 28754427. IF: 4,061.

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